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Journal Publication
Research Title Hepatoprotective activity of bergenin against ethanol-induced oxidative stress in male ICR mice 
Date of Distribution 16 March 2019 
Conference
     Title of the Conference The 11th Annual Northeast Pharmacy Research Conference of 2019 
     Organiser คณะเภสัชศาสตร์ มหาวิทยาลัยมหาสารคาม มหาวิทยาลัยขอนแก่น และมหาวิทยาลัยอุบลราชธานี 
     Conference Place คณะเภสัชศาสตร์ มหาวิทยาลัยมหาสารคาม 
     Province/State มหาสารคาม 
     Conference Date 16 March 2019 
     To 17 March 2019 
Proceeding Paper
     Volume
     Issue
     Page 16 
     Editors/edition/publisher  
     Abstract Introduction: Bergenin is a C-glucoside of 4-O-methylgallic acid. Bergenin has been claimed to possess anti-oxidant, anti-inflammatory, and anti-hyperglycemic activities. This study aimed to evaluate hepatoprotective activity of bergenin against ethanol-induced oxidative stress in mice. Materials and methods: The 8-week-old male ICR mice were orally given bergenin (10, 50, and 250 mg/kg/day) or gallic acid (100 mg/kg/day, positive control) for 7 days before single oral administration of ethanol (5 g/kg/day), while the control group was simply orally given water. Liver injury biomarkers in mouse serum, e.g. aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and antioxidant enzymes in mouse liver, e.g. superoxide dismutase (SOD) and catalase (CAT) were examined. Results: The levels of serum AST and ALT were significantly increased in ethanol-induced oxidative stress mice, in accordance with a significant decrease in hepatic SOD and CAT activities, compared with control group (p<0.05). Bergenin significantly decreased the levels of serum AST and ALT along with a significant increase in hepatic SOD and CAT activities, compared with the ethanol-induced oxidative stress mice (p<0.05). Correspondingly, gallic acid showed a tendency to reduce the serum ALT level with a significant decrease in the serum AST level and a significant increase in hepatic SOD and CAT activities in ethanol-induced oxidative stress mice, compared with the ethanol-induced oxidative stress mice (p<0.05). Conclusion: Ethanol increased serum AST and ALT levels and reduced hepatic SOD and CAT activities leading to oxidative stress in mice. Bergenin exhibited hepatoprotective potential via balancing oxidant-antioxidant system; to decrease serum AST and ALT levels and to promote hepatic SOD and CAT activities, comparable to those did by gallic acid. Therefore, bergenin is an ultimate candidate for further development as hepatoprotective products 
Author
607150008-1 Miss YOLLADA SRISET [Main Author]
Pharmaceutical Sciences Doctoral Degree

Peer Review Status มีผู้ประเมินอิสระ 
Level of Conference ชาติ 
Type of Proceeding Abstract 
Type of Presentation Oral 
Part of thesis true 
Presentation awarding false 
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