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Title of Article Mucoadhesive sustained-release tablets for vaginal delivery of Curcuma comosa extracts: Preparation and characterization 
Date of Acceptance 18 March 2019 
Journal
     Title of Journal Journal of Drug Delivery Science and Technology 
     Standard SCOPUS 
     Institute of Journal elsevier 
     ISBN/ISSN  
     Volume 2019 
     Issue 51 
     Month June
     Year of Publication 2019 
     Page 559-568 
     Abstract The objectives of this study were to prepare and characterize the mucoadhesive vaginal tablets of Curcuma comosa (C. comosa) extract for local delivery of the active phytoestrogens in a sustained release manner. The oleoresin-like C. comosa extract was converted into apparently dry powder by adding it into the mixture of polymer, namely polycarbophil (PCP), hydroxypropylmethylcellulose (HPMC) or the blends of PCP:HPMC, and silica. The absence of interaction between C. comosa extract and excipients was confirmed using FTIR. C. comosa mucoadhesive powder was directly compressed into 24-mm capsule shape tablets. All prepared tablets had acceptable physical properties and uniformity of diarylheptanoids (DAs), namely (3R)-1,7-diphenyl-(4E,6E)-4,6-heptadien-3-ol (DA1) and (3S)-1,7-diphenyl-(6E)-4,6-hepten-3-ol (DA2). Blending PCP with HPMC could improve swelling and mucoadhesive properties of the tablets (p < 0.05). In vitro release showed that DAs were released over a period of 72 h in a sustained manner. The almost complete DA release was found in the formulation prepared with HPMC, of which the mean dissolution time of DA1 and DA2 stood at 34.7 ± 4.1 and 32.1 ± 3.7 h, respectively. Stability study reveals that C. comosa tablets were stable in terms of tablet properties, DA content and release characteristics when stored in a refrigerator. 
     Keyword Curcuma comosaVaginal tabletsMucoadhesiveHydroxypropylmethylcellulosePolycarbophil 
Author
595150001-0 Miss PAMIKA TUNPANICH [Main Author]
Pharmaceutical Sciences Master's Degree

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Level of Publication นานาชาติ 
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