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Publication
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| Title of Article |
Induction of Colitis in Experimental Animals : A Review |
| Date of Acceptance |
8 November 2017 |
| Journal |
| Title of Journal |
วารสารเภสัชศาสตร์อีสาน (Isan Journal of Pharmaceutical Sciences, IJPS) |
| Standard |
TCI |
| Institute of Journal |
คณะเภสัชศาตร์ มหาวิทยาลัยขอนแก่น, มหาวิทยาลัยมหาสารคาม, มหาวิทยาลัยอุบลราชธานี |
| ISBN/ISSN |
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| Volume |
13 |
| Issue |
4 |
| Month |
ตุลาคม-ธันวาคม |
| Year of Publication |
2017 |
| Page |
1-10 |
| Abstract |
Inflammatory bowel disease (IBD) is a complex multifactorial disease that involves all or part of digestive tract consists of two forms; Crohn’s disease (CD) and ulcerative colitis (UC). However, the etiology of the disease remains elusive and unclear. Hence, an experimental animal model becomes to be recognized as a valuable method and indispensable tool to provide a wide range of options for investigating the mechanism and disease pathophysiology and also facilitate the study on preclinical design to target specific components. The objective of this review is to summarize models for induction of colitis in experimental animals. These models are categorized by the principles and causes of colitis induction, in which these are divided into 4 categories, i.e., chemical induced colitis model, bacterial induced colitis model, adoptive cell transferred colitis model, and transgenic or gene- knockout colitis model. Thus, the optimal model is individual consideration depended on the aim of the study to obtain the informative and applicable data. |
| Keyword |
Colitis, Inflammatory bowel disease, Animal model |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
ชาติ |
| citation |
true |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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