2012 ©
Journal Publication
Title of Article Opisthorchis viverrini infection augments the severity of nonalcoholic fatty liver disease in high-fat/high-fructose diet-fed hamsters 
Date of Acceptance 29 July 2019 
     Title of Journal American Journal of Tropical Medicine & Hygiene 
     Standard ISI 
     Institute of Journal American society of tropical medicine and hygieneiety 
     Year of Publication 2019 
     Abstract The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide, including in regions where helminth infections such as the fish-borne liver fluke Opisthorchis viverrini (Ov) also occur. We investigated the effects of a high-fat and high-fructose (HFF) diet on development and progression of NAFLD in experimental opisthorchiasis. Two groups of hamsters were infected with O. viverrini for four months prior to the experiment to induce chronic inflammation. One of these groups (OvHFF) was fed with HFF diet for up to a further four months. One uninfected group of hamsters served as the normal control (NC) group, another received the HFF diet (HFF group) for up to four months. Histopathology, biochemical parameters and ultrastructural features of liver were investigated. In a short-term treatment, the OvHFF group showed significantly better homeostatic model assessment for insulin resistance level and lower liver lipid than did the HFF group. By contrast, histopathological characteristics of severe NAFLD were prominent in the OvHFF group after four months on the HFF diet, findings which were supported by confirmatory ultrastructural changes. In conclusion, opisthorchiasis induced the severe NAFLD in hamsters fed high- fat/high-fructose diets. 
     Keyword Opisthorchiasis, Nonalcoholic fatty liver, Nonalcoholic steatohepatitis, High-fat/high-fructose diet 
557070026-9 Mr. APISIT CHAIDEE [Main Author]
Medicine Doctoral Degree
Medicine Doctoral Degree
547100011-6 Mr. KITTI INTUYOD
Graduate School Doctoral Degree
587070027-0 Miss ORNUMA HAONON
Medicine Doctoral Degree

Reviewing Status มีผู้ประเมินอิสระ 
Status ได้รับการตอบรับให้ตีพิมพ์ 
Level of Publication นานาชาติ 
citation true 
Part of thesis true 
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