| Title of Article |
Opisthorchis viverrini infection augments the severity of nonalcoholic fatty liver disease in high-fat/high-fructose diet-fed hamsters |
| Date of Acceptance |
29 July 2019 |
| Journal |
| Title of Journal |
American Journal of Tropical Medicine & Hygiene |
| Standard |
ISI |
| Institute of Journal |
American society of tropical medicine and hygieneiety |
| ISBN/ISSN |
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| Volume |
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| Issue |
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| Month |
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| Year of Publication |
2019 |
| Page |
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| Abstract |
The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide, including in regions where helminth infections such as the fish-borne liver fluke Opisthorchis viverrini (Ov) also occur. We investigated the effects of a high-fat and high-fructose (HFF) diet on development and progression of NAFLD in experimental opisthorchiasis. Two groups of hamsters were infected with O. viverrini for four months prior to the experiment to induce chronic inflammation. One of these groups (OvHFF) was fed with HFF diet for up to a further four months. One uninfected group of hamsters served as the normal control (NC) group, another received the HFF diet (HFF group) for up to four months. Histopathology, biochemical parameters and ultrastructural features of liver were investigated. In a short-term treatment, the OvHFF group showed significantly better homeostatic model assessment for insulin resistance level and lower liver lipid than did the HFF group. By contrast, histopathological characteristics of severe NAFLD were prominent in the OvHFF group after four months on the HFF diet, findings which were supported by confirmatory ultrastructural changes. In conclusion, opisthorchiasis induced the severe NAFLD in hamsters fed high- fat/high-fructose diets. |
| Keyword |
Opisthorchiasis, Nonalcoholic fatty liver, Nonalcoholic steatohepatitis, High-fat/high-fructose diet |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ได้รับการตอบรับให้ตีพิมพ์ |
| Level of Publication |
นานาชาติ |
| citation |
true |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Publication
Journal Publication
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