| Research Title |
Ursolic acid inhibits proliferation and induces apoptosis through biomolecular changes in cholangiocarcinoma cells |
| Date of Distribution |
28 September 2019 |
| Conference |
| Title of the Conference |
The 78th Annual Meeting of the Japanese Cancer Association |
| Organiser |
Japanese Cancer Association |
| Conference Place |
Kyoto International Conference Center |
| Province/State |
เกียวโต ประเทศ ญี่ปุ่น |
| Conference Date |
26 September 2019 |
| To |
28 September 2019 |
| Proceeding Paper |
| Volume |
78 |
| Issue |
1 |
| Page |
204 |
| Editors/edition/publisher |
|
| Abstract |
The Northeast of Thailand has the highest incidence of cholangiocarcinoma (CCA), a bile duct cancer, worldwide. CCA in this region is associated with Opisthorchis viverrini infection. CCA patients usually present with late-stage disease. Current treatments for CCA give unsatisfactory results. New and more effective forms of therapy for CCA are urgently needed. Ursolic acid (UA), a natural triterpene, exhibits the anti-cancer activities, e.g., suppressing proliferation and inducing apoptosis. The objectives of the present study were to: i) evaluate the cytotoxic effect of UA against CCA cells; ii) investigate UA-induced biomolecular changes by synchrotron radiation-based Fourier-transform infrared microspectroscopy (SR-FTIRM); and iii) detect apoptosis using flow cytometry. The results showed that UA inhibited CCA cell proliferation in a dose- and time-dependent manner. The SR-FTIRM results revealed significant modifications in the absorption bands of proteins and lipids, supporting the ability of UA to induce apoptosis. Flow cytometric data confirmed apoptosis-inducing property of UA and membrane changes during apoptosis. Thus, UA may be a promising candidate for CCA treatment. |
| Author |
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| Peer Review Status |
ไม่มีผู้ประเมินอิสระ |
| Level of Conference |
นานาชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Oral |
| Part of thesis |
true |
| Presentation awarding |
true |
| Award Title |
Sister Hirose Travel Award |
| Type of award |
รางวัลด้านวิชาการ วิชาชีพ |
| Organiser |
Sister Hirose, Japanese Cancer Association |
| Date of awarding |
28 กันยายน 2562 |
| Attach file |
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| Citation |
0
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Publication
Journal Publication
ไทย