| Research Title |
Helicobacter pylori infection promote cholangiocarcinoma development in hamstes |
| Date of Distribution |
27 September 2019 |
| Conference |
| Title of the Conference |
The 78th Annual Meeting of the JCA |
| Organiser |
Kyoto University Graduate School of Biostudies |
| Conference Place |
Kyoto International Conference Center |
| Province/State |
Japan |
| Conference Date |
26 September 2019 |
| To |
28 September 2019 |
| Proceeding Paper |
| Volume |
78 |
| Issue |
78 |
| Page |
161 |
| Editors/edition/publisher |
|
| Abstract |
Several lines of evidence underlined Opisthorchis viverrini (Ov) infection; endemic in Greater Mekong Subregion; is strongly related with CCA. Previous studies reported the presence of Helicobacter
pylori (Hp) in bile derived from CCA and cholelithiasis patients, suggesting its contribution to pathogenesis of these diseases. This study aimed to investigate the effect of H. pylori infection on CCA
development; both with and without liver fluke infection in hamsters. Fifty hamsters were divided into five groups: (1) Normal, (2) N-Nitrosodimethylamine (NDMA), (3) Hp+NDMA, (4) Ov+NDMA, and
(5) Hp+Ov+NDMA. The precancerous lesions were observed in group 4 and 5 at 3-month post-induction. CCA development was found in group 3, 4 and 5 but earlier in group 4 and 5. The lowest of
survival rate was found in the Hp+Ov+NDMA group (42.6%) with occasional appearance of liver abscess. The highest of liver weight to body weight ratio was also observed in this group. In conclusion,
a combination of H. pylori infection and carcinogen, both with and without liver fluke infection, can induce CCA development in experimental hamsters. |
| Author |
|
| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
นานาชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Poster |
| Part of thesis |
true |
| Presentation awarding |
false |
| Attach file |
|
| Citation |
0
|
|
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Publication
Journal Publication
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