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Publication
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| Title of Article |
The Combination of SLC2A9 Gene (rs2280205 and rs6820230) and Major Metabolic Factors with Association to Gout in Thai Men; A Matched Case-Control Study |
| Date of Acceptance |
25 February 2020 |
| Journal |
| Title of Journal |
Indian Journal of Public Health Research & Development |
| Standard |
SCOPUS |
| Institute of Journal |
Institute of Medico-Legal Publications |
| ISBN/ISSN |
0976-0245 |
| Volume |
11 |
| Issue |
4 |
| Month |
April |
| Year of Publication |
2020 |
| Page |
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| Abstract |
A combination of non-synonymous variants, rs2280205 and rs6820230 of the SLC2A9 gene, and major metabolic parameters contribute to developing gout remains not well studied or assessed in Thai men. This study was conducted to assess the association between combined of two non-synonymous variants and gout. Using data from male subjects of age ≥ 20 years in the Genetic variation of Urate transporter genes in Hyperuricemia and Gout among Thai population Study (GUHGTHS). We randomly performed a 1:1 age-matched case-control study that included 48 gout patients and 48 non-gout subjects. Using multivariate logistic regression analysis was used to analyze data. The single and joint locus effect of rs2280205 and rs6820230 variants were independently associated with gout. However, the combination of rs2280205 and high fasting glucose, including rs6820230 variant and high fasting glucose were associated with gout, the adjusted odds ratio was 13.70-fold and 5.81-fold, respectively. Meanwhile, we did not observe an association between these variants and high blood pressure, including general obesity with gout.
In conclusion, rs2280205 and rs6820230 variants did independently associated with increased risk of gout, but predominantly occurred in high fasting glucose subjects. However, further studies with larger sample sizes and homogeneous populations should be confirmed these results. |
| Keyword |
rs2280205 variant, rs6820230 variant, gout, metabolic parameters |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ได้รับการตอบรับให้ตีพิมพ์ |
| Level of Publication |
นานาชาติ |
| citation |
false |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
ไทย