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Publication
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| Title of Article |
Quercetin enhances phenformin in inhibition of cholangiocarcinoma cells |
| Date of Acceptance |
17 March 2020 |
| Journal |
| Title of Journal |
Srinagarin Medical Journal |
| Standard |
TCI |
| Institute of Journal |
ฝ่ายวิชาการ คณะแพทยศาสตร์ มหาวิทยาลัยขอนแก่น |
| ISBN/ISSN |
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| Volume |
35 |
| Issue |
3 |
| Month |
May-June |
| Year of Publication |
2020 |
| Page |
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| Abstract |
Background and Objective: Phenformin, quercetin, and myricetin, a flavonoid in the same group, are effective against many types of cancers. This study evaluated the treatments of phenformin in combination with quercetin or myricetin in the inhibition of cholangiocarcinoma (CCA) cells.
Methods: Cholangiocarcinoma cells, KKU-156, were used in this study. Cell cytotoxicity was evaluated by sulforhodamine-B assay (SRB). Mitochondrial membrane potential (m) was analyzed by JC-1 assay.
Results: Phenformin significantly inhibits proliferation of cancer cells. Phenformin in combination with quercetin, but not myricetin, could increase the cytotoxicity of cancer cells. Phenformin, quercetin or in the combination induced the loss of mitochondrial transmembrane potential.
Conclusions: Quercetin increased phenformin in inhibition of cancer cell growth. The mechanism may be by the increase of induction of mitochondrial damage leading to cell death. This finding suggests that phenformin in combination with quercetin has potential to increase efficacy of chemotherapy of cholangiocarcinoma.
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| Keyword |
Phenformin, quercetin, myricetin, cholangiocarcinoma, mitochondrial transmembrane potential |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ได้รับการตอบรับให้ตีพิมพ์ |
| Level of Publication |
ชาติ |
| citation |
true |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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