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Publication
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| Title of Article |
Anti-Hemorrhoidal Activity of Pluchea indica Leaves Aqueous Extract in Croton Oil-Induced Hemorrhoids in Experimental Animals. |
| Date of Acceptance |
22 June 2019 |
| Journal |
| Title of Journal |
ศรีนครินทร์เวชสาร (Srinagarind Med J) |
| Standard |
TCI |
| Institute of Journal |
ศรีนครินทร์เวชสาร |
| ISBN/ISSN |
Srinagarind Med Journal |
| Volume |
34 |
| Issue |
6 |
| Month |
11 |
| Year of Publication |
2019 |
| Page |
590-594 |
| Abstract |
Background and Objective: Pluchea indica (L.) Less
(“Khlu” in Thai) is traditionally used as a folk medicine
for the treatment of many diseases and Pluchea
indica leaves tea is quite famous and used to help
cure hemorrhoids without any scientific evidences.
This study focused on the investigation of the effects
of aqueous extract of Pluchea indica leaves on the
movement of gastrointestinal tract in mice and the
croton oil-induced hemorrhoid in rats.
Methods: The effects of Pluchea indica leaves
aqueous extract (PIE) at the doses of 50, 100 or 150
mg/kg on whole gut transit time and intestinal transit
rate in male ICR mice were tested using the charcoal
test. Male Wistar rats were forced fed with PIE at 50
mg/kg/day once daily for 10 consecutive days. On day
5, the animals were induced to be hemorrhoids by
inserted cotton bud swab soaked with cotton oil
preparation (100 μl) into the anus. Rats were killed
on day 11, anus and spleens are removed and weighed
and macroscopic changes of the rectum were
observed.
Results: Oral administration of PIE at either 50, 100
or 150 mg/kg had no effect on whole gut transit time
or intestinal transit rate in mice. PIE at 50 mg/kg/day
could significantly attenuate the severity of the croton
oil-induced hemorrhoids in rats as seen by a significant
reduction of spleen and rectum weights and the
severity of the rectal damage was significantly reduced.
Conclusions: The result of this study supported the
effectiveness of the traditional use of Pluchea indica
leaves tea in the treatment of hemorrhoids. However,
at the doses tested, no effect on the gastrointestinal movement was seen. |
| Keyword |
Pluchea indica, whole gut transit time, intestinal transit rate, hemorrhoids, experimental animals |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
ชาติ |
| citation |
true |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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