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Publication
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| Title of Article |
Effect of captopril on erectile dysfunction and sperm quality in hypertensive rats |
| Date of Acceptance |
17 August 2020 |
| Journal |
| Title of Journal |
Srinagarind Medical Journal |
| Standard |
TCI |
| Institute of Journal |
ฝ่ายวิชาการ คณะแพทย์ศาสตร์ มหาวิทยาลัยขอนแก่น |
| ISBN/ISSN |
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| Volume |
35 |
| Issue |
6 |
| Month |
พฤศจิกายน-ธันวาคม |
| Year of Publication |
2020 |
| Page |
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| Abstract |
Background and Objectives: Hypertension has been reported to be associated with erectile and testicular dysfunction. This study aimed to evaluate the role of the anti-hypertensive drug, captopril, on erectile and testicular function in L-NAME-induced hypertensive rats.
Methods: Male Sprague-Dawley rats were divided into 3 groups including control group received tap water, L-NAME group received L-NAME at dose 40 mg/kg/day for five weeks and captopril group received L-NAME and captopril at dose 5 mg/kg/day for the last two weeks. At the end of the study, systolic blood pressure, erectile response to nerve stimulation, sperm concentration, sperm motility, and oxidative stress markers were determined.
Results: L-NAME administration caused high blood pressure and decreased erectile response to nerve stimulation, reduced sperm concentrations, and sperm motility in rats. Moreover, the high level of vascular superoxide production, plasma, and tissue malondialdehyde, and low level of plasma nitric oxide metabolites were also observed in hypertensive rats compared to control rats (p<0.05). Treatment with captopril alleviated these reproductive alterations caused by L-NAME.
Conclusion: Captorpil improved erectile dysfunction and sperm quality in L-NAME-induced hypertensive rats. The possible mechanism may associate with its antihypertensive and antioxidant properties.
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| Keyword |
Captopril, erectile dysfunction, L-NAME hypertensive rats, sperm, oxidative stress |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ได้รับการตอบรับให้ตีพิมพ์ |
| Level of Publication |
ชาติ |
| citation |
false |
| Part of thesis |
true |
| Attach file |
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| Citation |
6
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Journal Publication
ไทย