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Publication
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| Title of Article |
Vitamin C supplementation improves blood pressure and oxidative stress after acute exercise in patients with poorly controlled type 2 diabetes mellitus: a randomized, placebo- controlled, crossover study |
| Date of Acceptance |
8 December 2020 |
| Journal |
| Title of Journal |
Chinese Journal of Physiology |
| Standard |
SCOPUS |
| Institute of Journal |
Chinese Physiological Society |
| ISBN/ISSN |
ISSN 0304-4920; e-ISSN 2666-0059 |
| Volume |
- |
| Issue |
- |
| Month |
- |
| Year of Publication |
2020 |
| Page |
- |
| Abstract |
Abst rac t :
This study aimed to asses s the effect of vitamin C on blood pres sur e (BP) , and
subseque n t ly on oxidative stres s and nitric oxide releas e, following the lowintensi
ty exercise in the patient s . This study included 24 patient s with type 2
diabet e s mellitus (T2D) (age, 53 ± 7 yr; hemoglobin A1c, 10.1% ± 0.9%)
randomiz ed into two six-week daily arms based on consumpt ion of eithe r
placebo or 1,000 mg of vitamin C. The crossove r trial occur r ed after a six-week
washout . Before and after both the suppleme nt a t ion arms, all patient s
performed cycling exercise at 33% of peak oxygen consumpt ion for 20 min. BP
were measur e d before, immedia t ely, and 60 min after the exercise. Blood
samples were drawn before and immedi at ely after the exercise to determine
plasma ascorba t e , malondialdehyde, F 2-isopros t an e s , and nitric oxide
concent r a t ions . Data showed significant lower BP in the vitamin C arm when
compa r e d with the placebo arm (SBP P < 0.001 at every time point, DBP P <
0.001 except at immedi at ely after exercise, P < 0.05). Plasma ascorba t e
concent r a t ion (P < 0.05 at every time point) and plasma nitric oxide (at resting
P < 0.001, immedia t ely after exercise P < 0.05) were significantly incre a s e d in
the vitamin C arm than in the placebo arm . Plasma malondialdehyde (P < 0.05
at every time point) and F 2-isopros t an e s (P < 0.05 at every time point)
concent r a t ions were significant ly lower in the vitamin C arm than in the placebo
1
arm. In addition, data showed significantly lower SBP (P < 0.001 at every time
point ), DBP (P < 0.001 except at immedi a t ely after exercise P < 0.05) , plasma
malondialdehyde (P < 0.001 at every time point) , and F 2 -isopros t ane s (P < 0.05
at every time point ) at post- suppleme n t a t ion than at pre- suppleme nt a t ion.
Besides, ther e were significant ly highe r plasma ascorba t e (P < 0.05 at every
time point ) and nitric oxide (at res t P < 0.01, immediat ely after exercise P <
0.05) concent r a t ions at post- suppleme nt a t ion than at pre- suppleme nt a t ion. This
is in cont r a s t to the placebo supplemen t a t ion arm which demons t r a t e d no
statis tical differenc e in all outcome s throughout the experiment . This study
sugge s t s that six-week vitamin C suppleme n t a t ion decre a s e d pre- exercise and
post- exercise BPs, possibly due to improved oxidative stres s and nitric oxide releas e. Howeve r , exercise had no effect on any outcome measur e s . |
| Keyword |
Ascorbic acid, physical activity, hyperglycemi a, hyper t ens ion,malondialdehyde, F 2-isopros t an e s |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ได้รับการตอบรับให้ตีพิมพ์ |
| Level of Publication |
นานาชาติ |
| citation |
true |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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