| Abstract |
Type 2 diabetes mellitus (T2DM) is a worldwide health problem. The numbers of patients increase much more rapidly. Low levels of anti-oxidant such as vitamin C in T2DM patients have been reported and these were accompanied by high levels of lipid peroxidation. Supplementation with vitamin C has been shown to have beneficial effects on oxidative condition and metabolic system as well as immune status, especially, in poorly controlled T2DM. To understanding the effect of vitamin C at a molecular level, we examined circulating microRNAs (miRNAs) in response to vitamin C supplementation in T2DM. The study was designed in a double blind, placebo-controlled, randomized crossover with either a 1,000 mg vitamin C or placebo daily for six weeks with a six-week washout period. Six participants who had increased vitamin C level, antioxidant and polymorphonuclear function were selected to screen for miRNA expression and compared between pre-and post-vitamin C consumption using miRNA microarray. The results demonstrated that miR-513a-3p was significantly increased after vitamin C supplementation (1.47-fold increase, P=0.03). This data indicated that consumption of vitamin C affected miRNA expression in uncontrolled T2DM patients. The alteration of miRNA expression may be related to increased anti-oxidative activities and polymorphonuclear function of T2DM and awaits further functional studies. |
Publication
Journal Publication
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