|
|
Publication
|
| Title of Article |
Profiling of
Bile Microbiome Identifies District Microbial Population between Choledocholithiasis and
Cholangiocarcinoma Patients |
| Date of Acceptance |
4 January 2021 |
| Journal |
| Title of Journal |
Asian Pacific Journal of Cancer Prevention |
| Standard |
SCOPUS |
| Institute of Journal |
Dept of Social Medicine, Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran |
| ISBN/ISSN |
|
| Volume |
|
| Issue |
Vol 22 |
| Month |
|
| Year of Publication |
2021 |
| Page |
253-260 |
| Abstract |
Objective: Choledocholithiasis (CDL), a potential risk for cholangiocarcinoma (CCA) development, is often a
consequence of bacterial infection. Thus, the microbial population that contributes to CDL might also be involved
in CCA development. We compared the microbiome in bile fluid of CDL patients and CCA patients. Methods: Bile
samples were collected from CDL (n = 30) and CCA (n =30) patients. Microbial profiling was performed individually by
the sequencing of V3-V4 regions of the 16S rRNA gene. Results: Enterobacter, Pseudomonas, and Stenotrophomonas
species were much more abundant in bile samples from CCA compared to CDL (p<0.05). However, Cetobacterium,
Pyramidobacter, and Streptococcus species were less abundant in bile samples of CCA compared to CDL (p<0.05).
Although Escherichia was predominant in the CCA, Escherichia coli itself was more abundant in CDL than in CCA.
One CDL case (3.3%) harbored genotoxin-producing E. coli as confirmed by PCR. Enterobacter and Pseudomonas
also predominated in CCA according to linear discriminant-analysis effect size. Conclusion: we demonstrated vast
differences between microbial communities in bile of CDL and CCA patients. These bacteria might be partly involved
in CCA genesis and may provide novel biomarkers for CCA |
| Keyword |
Bile microbiome- cholangiocarcinoma- choledocholithiasis- genotoxin-producing E. coli |
| Author |
|
| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ได้รับการตอบรับให้ตีพิมพ์ |
| Level of Publication |
นานาชาติ |
| citation |
true |
| Part of thesis |
true |
| Attach file |
|
| Citation |
0
|
|
|
|
|
|
|
|
|
Journal Publication
ไทย