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Publication
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| Title of Article |
Topical melatonin niosome gel for the treatment of 5-FU-induced oral mucositis in mice |
| Date of Acceptance |
23 May 2020 |
| Journal |
| Title of Journal |
Current drug delivery |
| Standard |
ISI |
| Institute of Journal |
Bentham Science Publishers |
| ISBN/ISSN |
1875-5704 |
| Volume |
2021 |
| Issue |
18 |
| Month |
มกราคม |
| Year of Publication |
2021 |
| Page |
199 - 211 |
| Abstract |
Background: Oral mucositis, one of the most common complications of 5-fluorouracil
(5-FU) treatment, leads to several problems, including pain, diarrhea and malnutrition, and reduces
the quality of life and subsequent treatments. Melatonin, a neurohormone with anti-inflammatory
and antioxidant activities, was encapsulated in niosomes and embedded in a mucoadhesive gel formulation as a Melatonin Niosome Gel (MNG) to perform oral mucositis treatment.
Objective: This study aimed to investigate the effectiveness of MNG for the treatment of 5-FU-induced oral mucositis in mice.
Methods: Oral mucositis was induced in ICR mice by 5-FU and randomly assigned to receive daily applications of the topical oral MNG, a fluocinolone acetonide gel, a blank niosome gel, or no
treatment for 5 days in comparison with a normal group. Average body weights, food consumption, and behaviors of the mice as well as microscopic histopathology, Fourier-Transform Infrared
Spectroscopy (FTIR) analysis, proinflammatory cytokine levels, and oxidative stress markers of
the tongues were monitored and collected after sacrifice.
Results: In comparison to the normal group, the average body weights of the 5-FU-MNG mice did
not deviate from that of the normal group, nor was there a significant difference in the time to sleep
or licking (p>0.05 for both parameters). In addition, the mice treated with MNG and fluocinolone
acetonide did not show significantly different histopathological, FTIR, interleukin-1β or malondialdehyde (MDA) results in the tongues used as the oral tissue samples.
Conclusion: Topical MNG potentially inhibits inflammation and lipid oxidative stress in 5-FU-induced oral mucositis. |
| Keyword |
Niosomes, Melatonin, 5-Fluorouracil, Mucositis, Anti-inflammation, Antioxidant, Malondialdehyde (MDA) |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ได้รับการตอบรับให้ตีพิมพ์ |
| Level of Publication |
นานาชาติ |
| citation |
false |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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