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Publication
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| Title of Article |
Oral administration of melatonin or succinyl melatonin niosome gel benefits 5-FUinduced small intestinal mucositis treatment in mice |
| Date of Acceptance |
20 January 2021 |
| Journal |
| Title of Journal |
AAPS PharmSciTech |
| Standard |
ISI |
| Institute of Journal |
springer |
| ISBN/ISSN |
1530-9932 |
| Volume |
2021 |
| Issue |
- |
| Month |
- |
| Year of Publication |
2021 |
| Page |
- |
| Abstract |
Mucositis is one of the most adverse effects of 5-fluorouracil (5-FU) and had no standard
drug for treatment. Melatonin is a neurohormone, can ameliorate radiotherapy-induced small
intestinal mucositis. Melatonin encapsulated in niosomes improved its poor bioavailability.
Succinyl melatonin, a melatonin derivative, showed prolonged release compared with
melatonin. This study investigated the efficacy of melatonin niosome gel (MNG) and
succinyl melatonin niosome gel (SNG) in 5-FU-induced small intestinal mucositis treatment
in mice. MNG and SNG with particle sizes of 293 and 270 nm were shown to have
mucoadhesive potentials. The effect of a daily oral application of MNG, SNG, or
fluocinolone acetonide gel (FAG, positive control) was compared to that of the normal group.
The body weight, food consumption, histology, Fourier transform infrared (FTIR)
spectroscopy, inflammatory cytokines (tumor necrosis factor (TNF)-α and interleukin (IL)-
1β), and malondialdehyde (MDA) in the small intestine were monitored. The results showed
decreased %body weight and food consumption in all 5-FU-injected groups compared with
the normal group. The MNG and SNG treatments maintained the food consumption and the
normal integrity of the small intestines, as evidenced by villus length and crypt depth, similar
to the observations in the normal groups. The FTIR spectra showed no change in lipids of the
MNG and SNG groups compared with the normal group. Moreover, SNG could reduce IL-1β
content to a level that was not different from the level in the normal groups. Therefore, the
oral application of MNG and SNG could protect against 5-FU-induced small intestinal
mucositis in mice. |
| Keyword |
Melatonin, Succinyl melatonin, Niosome, 5-Fluorouracil, Small intestinal mucositis |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ได้รับการตอบรับให้ตีพิมพ์ |
| Level of Publication |
นานาชาติ |
| citation |
false |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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