|
|
Publication
|
| Research Title |
ATR-FTIR of mucoadhesive gel-treated mucosa: time and
temperature effects |
| Date of Distribution |
10 April 2018 |
| Conference |
| Title of the Conference |
2018 International Conference on Material Strength and Applied Mechanics (MSAM 2018) |
| Organiser |
MSAM 2018 Conference Organizing Committee Secretariat |
| Conference Place |
Kitakyushu International Conference Center |
| Province/State |
Kitakyushu, Fukuoka, Japan |
| Conference Date |
10 April 2018 |
| To |
13 April 2018 |
| Proceeding Paper |
| Volume |
- |
| Issue |
- |
| Page |
- |
| Editors/edition/publisher |
|
| Abstract |
Our previous developed melatonin niosome gel using poloxamer407, a
thermosensitive polymer with an advantage in facilitating fluid state at 25˚C and gel
state at 37˚C, was not able to differentiate adhesiveness by using mechanical testing.
ATR-FTIR, a highly sensitive method for detecting chemical interaction, was
interested for use to elaborate the effect of temperatures on chemical interaction
between mucosa and the melatonin niosome gel. In experiment, excised mucosa of
porcine esophagus was applied with blank niosome gel which composed of
poloxamer407, polyvinyl pyrrolidone and hydroxypropyl methylcellulose, and
melatonin niosome gel, at controlled temperatures of 25±2˚C and 37±2˚C for 1 and 5
min, and then analyzed by ATR-FTIR. The results showed that at 25 ˚C, a peak at
1551 cm-1 (N-H) was identified with samples of the mucosa treated by melatonin
niosome gel. At 37˚C, peaks at 1640 and 1551 cm-1 for C=O and N-H, respectively,
observed with melatonin niosome gel, while 1551 cm-1 with blank niosome gel.
Both treatments with melatonin niosome gel and blank niosome gel for 1 and 5 min
gave no difference, on FTIR spectra of the mucosa at 37˚C, representing body
temperature. In conclusion, there were changes in C=O and N-H interactions between
the mucoadhesive gel and the mucosa rapidly occurred at body temperature, which
could lead to explain the adhesive effect of the gel on the mucosa. |
| Author |
|
| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
นานาชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Oral |
| Part of thesis |
true |
| ใช้สำหรับสำเร็จการศึกษา |
ไม่เป็น |
| Presentation awarding |
false |
| Attach file |
|
| Citation |
0
|
|
|
|
|
|
|
|
|
Journal Publication
ไทย