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Publication
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| Title of Article |
Effect of ethanol on the changes in testicular protein expression in adult male rats |
| Date of Acceptance |
7 July 2020 |
| Journal |
| Title of Journal |
Andrologia. |
| Standard |
ISI |
| Institute of Journal |
Wiley Online Library |
| ISBN/ISSN |
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| Volume |
2020 |
| Issue |
52 |
| Month |
July |
| Year of Publication |
2020 |
| Page |
e13784 |
| Abstract |
Ethanol consumption is a major cause of male infertility, but the exact mechanism
is still largely unknown. This study attempted to investigate the effect of ethanol
on sperm morphology, acrosome reaction status and the alteration of the testicular
protein expressions. Fourteen male rats were divided into control and ethanol
groups (n = 7/each group). Ethanol-treated rats received ethanol (5 g/kg, 40% v/v) via
oral gavage for consecutive 14 days. Testosterone hormone, sperm parameters, and
testicular and epididymal histopathologies were evaluated. In addition, the expressions
of testicular proteins including androgen receptor (AR), heat shock protein 70
(HSP70), steroidogenic acute regulatory protein (StAR) and tyrosine-phosphorylated
(TyrPho) proteins were investigated. The results showed that ethanol significantly
increased percentage of abnormal sperm morphology and acrosome-reacted spermatozoa.
Some seminiferous and ductus epididymal histopathologies were observed
in ethanol-treated rats. Significantly, ethanol reduced serum testosterone and expressions
of testicular AR and TyrPho proteins. However, the overexpression of StAR
and HSP70 proteins in ethanol testis was found. It was concluded that the changes
in testicular protein expressions may be involved in mechanism of male infertility
caused from ethanol consumption. |
| Keyword |
ethanol, heat shock protein 70, male infertility, testicular proteins, tyrosine-phosphorylated protein |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
นานาชาติ |
| citation |
true |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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