2012 ©
             Publication
Journal Publication
Title of Article FOXM1c is the predominant FOXM1 isoform expressed in cholangiocarcinoma that associated with metastatic potential and poor prognosis of patients 
Date of Acceptance 14 April 2021 
Journal
     Title of Journal Heliyon 
     Standard OTHER (Scimago) 
     Institute of Journal Elsevier 
     ISBN/ISSN  
     Volume 2021 
     Issue
     Month April
     Year of Publication 2021 
     Page 1-7 
     Abstract Forkhead box M1 (FOXM1) is a transcriptional factor which plays an important role in oncogenesis. Four FOXM1 isoforms, FOXM1a, FOXM1b, FOXM1c and FOXM1d, are known so far. Different FOXM1 isoforms influence progression of cancer in different cancer types. In this study, the FOXM1c isoform and its impact in cholangiocarcinoma (CCA) was identified. FOXM1c was found to be the predominant isoform in patient-CCA tissues and cell lines. Detection of FOXM1c expression in CCA tissues reflected the worse prognosis of the patients, namely the advanced stage and shorter survival. Suppression of FOXM1 expression using siRNA considerably reduced migration and invasion abilities of CCA cell lines. RNA sequencing analysis revealed claudin-1 as a target of FOXM1. FOXM1 exhibited a negative correlation with claudin-1 expression which was demonstrated in patient CCA tissues and cell lines. FOXM1 may be a potential target for therapeutic treatment of the metastatic CCA. 
     Keyword FOXM1, Cholangiocarcinoma, Metastasis, RNA sequencing 
Author
597070007-7 Miss NATHAKAN KLINHOM-ON [Main Author]
Medicine Doctoral Degree

Reviewing Status มีผู้ประเมินอิสระ 
Status ได้รับการตอบรับให้ตีพิมพ์ 
Level of Publication นานาชาติ 
citation false 
Part of thesis true 
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