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Publication
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| Title of Article |
FOXM1c is the predominant FOXM1 isoform expressed in
cholangiocarcinoma that associated with metastatic potential and poor
prognosis of patients |
| Date of Acceptance |
14 April 2021 |
| Journal |
| Title of Journal |
Heliyon |
| Standard |
OTHER (Scimago) |
| Institute of Journal |
Elsevier |
| ISBN/ISSN |
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| Volume |
2021 |
| Issue |
7 |
| Month |
April |
| Year of Publication |
2021 |
| Page |
1-7 |
| Abstract |
Forkhead box M1 (FOXM1) is a transcriptional factor which plays an important role in oncogenesis. Four FOXM1
isoforms, FOXM1a, FOXM1b, FOXM1c and FOXM1d, are known so far. Different FOXM1 isoforms influence
progression of cancer in different cancer types. In this study, the FOXM1c isoform and its impact in cholangiocarcinoma
(CCA) was identified. FOXM1c was found to be the predominant isoform in patient-CCA tissues
and cell lines. Detection of FOXM1c expression in CCA tissues reflected the worse prognosis of the patients,
namely the advanced stage and shorter survival. Suppression of FOXM1 expression using siRNA considerably
reduced migration and invasion abilities of CCA cell lines. RNA sequencing analysis revealed claudin-1 as a target
of FOXM1. FOXM1 exhibited a negative correlation with claudin-1 expression which was demonstrated in patient
CCA tissues and cell lines. FOXM1 may be a potential target for therapeutic treatment of the metastatic CCA. |
| Keyword |
FOXM1, Cholangiocarcinoma, Metastasis, RNA sequencing |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ได้รับการตอบรับให้ตีพิมพ์ |
| Level of Publication |
นานาชาติ |
| citation |
false |
| Part of thesis |
true |
| ใช้สำหรับสำเร็จการศึกษา |
ไม่เป็น |
| Attach file |
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| Citation |
0
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Journal Publication
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