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Publication
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| Title of Article |
OXA-48-positive carbapenem-resistant Enterobacteriaceae in a farrow-to-finish pig farm: First report in Thailand |
| Date of Acceptance |
14 May 2021 |
| Journal |
| Title of Journal |
Veterinary Integrative Sciences |
| Standard |
SCOPUS |
| Institute of Journal |
The Faculty of Veterinary Medicine, Chiang Mai University, Thailand |
| ISBN/ISSN |
2629-9968 (online) |
| Volume |
19 |
| Issue |
3 |
| Month |
MAY |
| Year of Publication |
2021 |
| Page |
317-332 |
| Abstract |
Carbapenem-resistant Enterobacteriaceae (CRE) have emerged as an urgent threat to public health. This study aimed
to determine the occurrence of CRE and the carbapenemase genes in a farrow-to-finish pig farm, and to investigate
carriage proportion and maintenance of CRE during the pig production cycle. We conducted a cross-sectional study by
collecting 200 rectal swabs from healthy pigs of 5 groups: gilts, sows, piglets, weaners, and fatteners. In the longitudinal
study, 20 healthy pigs were followed from 2 to 26 weeks old, and rectal swabs were collected from each pig for 5 times.
Samples were screened for CRE using MacConkey agar supplemented with meropenem at 0.5 µg/mL. Identification and
antimicrobial susceptibility pattern of the recovered isolates were determined using an automated system. PCR was used to
detect carbapenemase genes. The occurrence of Enterobacteriaceae isolates with the carbapenem resistant phenotype and/or harboring the blaOXA-48 gene was 3% (6/200) in the cross-sectional study. Groups of sows and piglets had the same
occurrence rate at 5% (2/40), while weaner and fattener groups had 2.5% (1/40). In the longitudinal study, CRE were not detected in pigs at an early age; however, two isolates were detected at the age of finishing. This study is the first report of Enterobacteriaceae with a carbapenem resistant phenotype and/or carrying blaOXA-48 gene in pigs in Thailand. Finding
CRE in pigs at all age categories including finisher in the study farm underscores the need for active monitoring and surveillance studies to determine the occurrence of CRE in pig farms in Thailand. |
| Keyword |
Carbapenem resistance Enterobacteriaceae, Carbapenemase genes, Pigs, Thailand |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
นานาชาติ |
| citation |
false |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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