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Publication
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| Title of Article |
Low versus high 131I therapeutic effectiveness for differentiated thyroid cancer with intermediate risk of recurrence |
| Date of Acceptance |
30 April 2021 |
| Journal |
| Title of Journal |
Asia-Pacific Journal of Science and Technology |
| Standard |
SCOPUS |
| Institute of Journal |
The Research and Technology Transfer Affairs Division of Khon Kaen University |
| ISBN/ISSN |
2539-6293 |
| Volume |
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| Issue |
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| Month |
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| Year of Publication |
2021 |
| Page |
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| Abstract |
High 131I is recommended for treatment in the intermediate-to-high risk of recurrence of differentiated thyroid cancer (DTC). Since the lower 131I gives the lower side effects, the lower chance of secondary cancer, and the lower radiation hazard- reducing 131I doses with similar clinical outcomes is challenging. The aim of this study was to assess the clinical outcome, comparing between low (30 mCi) and high (150 mCi) 131I in DTC with intermediate risk of recurrence. All DTC with intermediate risk of recurrence between 2012 and 2019 were consecutively included. They were excluded if they had the blood tests of TSH of ≤ 25 µIU/L on the day before 131I oral administration or during the first diagnostic total body study or having received an injection of thyrotropin alfa, having previous treatment for thyroid cancer except for surgery, and having incomplete medical records. Six hundred sixty-six patients with DTC with intermediate risk of recurrence were included, 50 were in the low 131I and 616 were in the high 131I. Patients in the high 131I showed a higher odds of remission, with an adjusted odds ratio of 1.96 (95%CI: 1.01 to 3.81; p = 0.048), compared to the low 131I. Therapeutic effectiveness of the low 131I for the DTC with the intermediate risk of recurrence given a chance of lower than that of the high131I. Therefore, use of low 131I in patients who were in the misclassification of risk stratification of low-risk changing to intermediate-risk tended to be uncured. |
| Keyword |
Thyroid neoplasm, intermediate risk of recurrence, radioiodine therapy, therapeutic response |
| Author |
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| Reviewing Status |
ไม่มีผู้ประเมินอิสระ |
| Status |
ได้รับการตอบรับให้ตีพิมพ์ |
| Level of Publication |
นานาชาติ |
| citation |
false |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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