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Publication
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| Title of Article |
ผลป้องกันทางระบบประสาทของกรดคาเฟอิคต่อความบกพร่องของความจำที่ถูกเหนี่ยวนำด้วยแอล-เมไธโอนีนในหนูแรทโตเต็มวัย |
| Date of Acceptance |
9 September 2021 |
| Journal |
| Title of Journal |
ศรีนครินทร์เวชสาร (Srinagarind Medical Journal) |
| Standard |
TCI |
| Institute of Journal |
คณะแพทยศาสตร์ มหาวิทยาลัยขอนแก่น |
| ISBN/ISSN |
Srinagarind Medical Journal |
| Volume |
36 |
| Issue |
5 |
| Month |
กันยายน-ตุลาคม |
| Year of Publication |
2021 |
| Page |
591-596 |
| Abstract |
Background and objective: L-methionine is found in natural product such as meat, milk and serial grain. It is a non-essential amino acid and can be changed to homocysteine by methylation. Excess accumulation of homocysteine is a course of hyperhomocysteinemia and leads to memory deficit. Caffeic acid is a phenolic compound and found in coffee and tea. Several studies reported the neuroprotective effect of caffeic acid on memory and cognitive functions. Therefore, this study aimed to determine the neuroprotective effect of caffeic acid against L-methionine induced memory deficit.
Methods: 60 Male Sprague-Dawley rats were divided into 6 groups: control, L-met, caffeic acid 20, caffeic acid 40, caffeic acid 20+L-met, caffeic acid 40+L-met groups. The control group received propylene glycol and carboxymethyl cellulose by oral gavage. In the caffeic acid 20, caffeic acid 40, caffeic acid 20+L-met, caffeic acid 40+L-met groups, caffeic acid (20 and 40 mg/kg) and L-methionine (1.7 g/kg) groups were administered by oral gavage once a day for 28 days. Changes of spatial and recognition memory were examined using the novel object location (NOL) and novel object recognition (NOR) tests, respectively.
Results: The results demonstrate that caffeic acid (20 and 40 mg) and L-methionine did not have a negative effect on the body weight and locomotor activity. Impairments of spatial and recognition memories were found in the L-met group, but was not detected in the other groups
Conclusion: These results reveal that caffeic acid (20 and 40 mg) could potentially protect against L-methionine induced memory deficits.
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| Keyword |
กรดคาเฟอิค, แอล-เมไธโอนีน, ความจำบกพร่อง |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ได้รับการตอบรับให้ตีพิมพ์ |
| Level of Publication |
ชาติ |
| citation |
true |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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