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Publication
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| Title of Article |
Biliary Migration, Colonization, and Pathogenesis of
O. viverrini Co-Infected with CagA+ Helicobacter Pylori
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| Date of Acceptance |
26 August 2021 |
| Journal |
| Title of Journal |
Pathogens |
| Standard |
ISI |
| Institute of Journal |
MDPI |
| ISBN/ISSN |
ISSN 2076-0817 |
| Volume |
2021 |
| Issue |
10 |
| Month |
August |
| Year of Publication |
2021 |
| Page |
1089 |
| Abstract |
Co-infection with the cagA strain of Helicobacter pylori exacerbates the pathology of human liver fluke Opisthorchis viverrini (OV) infection leading to cholangiocarcinoma. However, underly- ing mechanisms remain unclear. We report a significant increase in cagA-positive and cagA-nega- tive H. pylori in the stomach, blood, bile, and in the OV worms of co-infected Syrian golden hamsters at one hour, three hours, and one month, post-infection, compared to hamsters infected with either OV or H. pylori alone. Except in the worms, H. pylori numbers declined at three months post-infec- tion, particularly in the bile fluid of co-infected animals. Both strains of H. pylori were immunohisto- chemically detected in the tegument of the worm, as well as in the bile duct epithelium when co- infected with O. viverrine, but not in H. pylori infection alone. Interestingly, only the cagA-positive strain was detected in the gut of the worm. Co-infection between cagA-positive H. pylori and O. viverrini resulted in a more severe biliary pathology and decreased E-cadherin expression in vivo and in vitro than those of the cagA-negative strain. These data suggest that O. viverrini acts as a carrier of cagA-positive H. pylori and co-migrates to the bile ducts, whereas O. viverrini facilitates H. pylori colonization and enhances the biliary pathogenesis and carcinogenesis. |
| Keyword |
Opisthorchis viverrini; Helicobacter pylori; co-infection; migration; colonization; pathogenesis |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
นานาชาติ |
| citation |
false |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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