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Publication
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| Title of Article |
Diosmetin attenuates metabolic syndrome and left
ventricular alterations via the suppression of
angiotensin II/AT1 receptor/gp91phox/p-NF-κB
protein expression in high-fat diet fed rats |
| Date of Acceptance |
22 December 2020 |
| Journal |
| Title of Journal |
Food and Function |
| Standard |
ISI |
| Institute of Journal |
Royal Society of Chemistry |
| ISBN/ISSN |
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| Volume |
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| Issue |
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| Month |
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| Year of Publication |
2020 |
| Page |
1469-1481 |
| Abstract |
Diosmetin, a monomethoxyflavone, is isolated from citrus fruits. The objective of this research was to test
the biological role of diosmetin on parameters of metabolic syndrome (MS) and left ventricular (LV) alterations in rats fed with a high-fat (HF) diet. MS was induced by feeding male Sprague-Dawley rats with a HF
diet plus 15% fructose in drinking water for 16 weeks. MS rats were given diosmetin (20 or 40 mg per kg
per day) or metformin (100 mg per kg per day) for the final four weeks. Diosmetin attenuated signs of MS
including, hypertension, hyperglycemia, insulin resistance, and dyslipidemia in rats that received the HF
diet (p < 0.05). A decreased stroke volume, ejection fraction, fractional shortening, LV hypertrophy and
fibrosis present in the MS group were alleviated by diosmetin treatment (p < 0.05). Diosmetin also suppressed angiotensin-converting enzyme activity, plasma angiotensin II (Ang II) levels and angiotensin II
type 1 (AT1) receptor protein expression in MS rats. Increases in superoxide (O2
•−) formation, plasma
malondialdehyde, plasma nitrate and nitrite and gp91phox expression induced by a HF diet were ameliorated in the diosmetin treated group. Inflammation indicated by an increased phospho nuclear factor
kappa B (p-NF-κB) protein expression and cardiac TNF-α concentration was reduced in MS rats receiving
diosmetin (p < 0.05). Metformin also attenuated MS, cardiac abnormalities relevant to decreasing the
renin–angiotensin system stimulation, reactive oxygen species and inflammation in MS rats (p < 0.05).
Diosmetin alleviated MS and LV dysfunction and remodeling in HF diet-induced MS rats. These results
could be associated with the suppression of the Ang II/AT1 receptor/gp91phox/p-NF-κB protein pathway. |
| Keyword |
Diosmetin, Metabolic syndrome, Vascular alteration, Angiotensin II |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
นานาชาติ |
| citation |
true |
| Part of thesis |
true |
| Attach file |
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| Citation |
3
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Journal Publication
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