| Research Title |
A Comparative Study of 20U and 50U of Intraoral Abobotulinum Toxin A (Dysport®) Injection
in Post Traumatic Trigeminal Neuropathic Pain Patients |
| Date of Distribution |
17 November 2021 |
| Conference |
| Title of the Conference |
The 18th International Scientific Conference of the Dental Faculty Consortium of Thailand (DFCT 2021) |
| Organiser |
Dental Faculty Consortium of Thailand |
| Conference Place |
Online Webinar |
| Province/State |
Chaingmai |
| Conference Date |
17 November 2021 |
| To |
19 November 2021 |
| Proceeding Paper |
| Volume |
2021 |
| Issue |
18th |
| Page |
233-237 |
| Editors/edition/publisher |
|
| Abstract |
Background: Botulinum Toxin A(BTX-A) has a growing evidence of its effectiveness in several neuropathic condi- tions such as post traumatic trigeminal neuropathic pain (PTTNP). However, studies for optimal dose and injection technique for its analgesic effect is still lacking.
Objectives: To investigate the efficacy and safety of 2 doses of BTX-A in patients suffering with PTTNP.
Methods: Thirteen PTTNP patients were enrolled in a 12-week, double blinded, randomized dose response trial of 2 fixed doses (20U and 50U) of BTX-A(Dysport®). Pain intensity was the primary outcome measured by visual analogue scale. Safety and tolerability were measured based on participant’s self-report using a daily pain diary. Mann-Whitney and Fischer’s Exact test were used for data analysis.
Results: Sixty-nine percent (n=9) of participants had significant pain reduction of ≥30% from baseline pain. Fifty-four percent of the total sample have experienced mild and transient side effects. There was no significant difference between 20U and 50U of BTX-A in the reduction of pain intensity. In addition, there was no association between dosage and the duration of analgesic effect and the occurrence of side effects.
Conclusions: BTX-A is a potential alternative treatment for PTTNP patients. These results suggest that a low dose of BTX-A for intraoral injection is sufficient and safe for pain relief.
Keywords: botulinum toxin a, post traumatic trigeminal neuropathy, orofacial pain |
| Author |
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| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
ชาติ |
| Type of Proceeding |
Full paper |
| Type of Presentation |
Oral |
| Part of thesis |
true |
| ใช้สำหรับสำเร็จการศึกษา |
ไม่เป็น |
| Presentation awarding |
false |
| Attach file |
|
| Citation |
6
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Publication
Journal Publication
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