| Abstract |
Clerodendrum petasites (CP) has been long used as Thai traditional medicine in treating fever. In particular, the root of CP is used in the 5-roots antipyretic formulations. Other parts, such as leaves and branches, have been identified as providing antipyretic properties in Thai medicinal text. The objective of this study is to compare the properties of methanol extracts of roots, leaves, and branches by DPPH, ABTS and FRAP assays, and cellular antioxidative activity by HaCaT cells. The results of CP in the DPPH and ABTS tests showed that there is no difference in the antioxidative activity. Whereas FRAP assay found that roots and branches extracts were more active than leaves (441.94 ± 33.61, 385.47 ± 29.60 and 222.36 ± 22.16 (µM) Fe2+ per g of extract, respectively). In cellular testing, all extracts at 62.5 and 250 µg/ml showed a similar cellular antioxidant capacity (CAA) unit (29.57 ± 0.91 to 45.38 ± 11.83 unit). The results of the study could be used as a guideline on how to use different parts of CP to produce the best benefit. In particular, different sections of CP may be used to substitute in the antipyretic formula as well. |
Publication
Journal Publication
ไทย