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Publication
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| Title of Article |
Anti-inflammatory and anti-proliferative activities of chemical constituents from fungus Biscogniauxia whalleyi SWUF13-085 |
| Date of Acceptance |
9 August 2021 |
| Journal |
| Title of Journal |
Phytochemistry |
| Standard |
SCOPUS |
| Institute of Journal |
© 2021 Elsevier Ltd |
| ISBN/ISSN |
00319422 |
| Volume |
2564 |
| Issue |
191 |
| Month |
สิงหาคม |
| Year of Publication |
2022 |
| Page |
112908 |
| Abstract |
The fungus Biscogniauxia whalleyi SWUF13-085 from the Graphostomataceae family was studied for potential anti-inflammatory and anticancer agents. A diverse array of natural products was identified. Six of which were undescribed compounds, including xylariterpenoids L-N, (1R,2S,6R,7S)-1,2-dihydroxy-α-bisabolol, 6-[(1R)-1hydroxy-1-methyl-2-propenyl]-4-methoxy-3-methyl-2H-pyran-2-one and (1R*,4S*,5S*,7S*,10R*)-guaia-11 (12)en-7,10-diol. Several of the isolated compounds such as bergamotene, guaiane and phthalide derivatives showed activity in both the inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells with IC50 values in the range of 2.48–10.82 μg/mL and anti-proliferation against HeLa cells with IC50 values in the range of 8.64–31.16 μg/mL. While compounds such as cerebrosides A and C only exhibited inhibitory effects on NO production with IC50 values in the range of 4.45–10.28 μg/mL. |
| Keyword |
Biscogniauxia whalleyi, Graphostomataceae, Anti-proliferative activity, Anti-inflammation NO production, Bergamotene, α-pyrone, Guaiane |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
นานาชาติ |
| citation |
true |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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