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Publication
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| Research Title |
Effects of curcumin-loaded nanocomplexes on Opisthorchis viverrini infection induced-cholangiocarcinoma in hamsters |
| Date of Distribution |
4 August 2021 |
| Conference |
| Title of the Conference |
International conference on Parasitology (ICP) 2021 |
| Organiser |
department of parasitology, faculty of medicine, khon kaen university |
| Conference Place |
Zoom meeting online |
| Province/State |
Khon Kaen |
| Conference Date |
3 August 2021 |
| To |
4 August 2021 |
| Proceeding Paper |
| Volume |
2 |
| Issue |
1 |
| Page |
32 |
| Editors/edition/publisher |
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| Abstract |
Introduction: Opisthorchiasis-associated cholangiocarcinoma (CCA) is one of the leading causes of death in the Greater Mekong Sub-regions, especially in the northeastern part of Thailand. Curcumin has been shown to possess a wide range of pharmacological actions including antiinflammation, anti-fibrosis, and also anti-cancer. Previously, curcumin has been shown the potential effect for chemoprevention of opisthorchiasis-associated CCA in vitro and in vivo. Nevertheless, curcumin has poor aqueous solubility, low bioavailability and is easily degraded by alkaline solution. In order to increase its efficacy, curcumin-loaded nanocomplexes (CNCs) were
developed. This study aimed to study the effect of CNCs for ameliorates of CCA in hamsters induced by Opisthorchis viverrini (OV) infection with N-Nitrosodimethylamine (NDMA). Methods: Ninety male golden Syrian hamsters were divided into five groups as follows: (1) normal (2) OV and NDMA-induced hamsters, and OV and NDMA-induced hamsters and supplement with either (3) blank nanocomplexes (BNCs) as placebo (4) CNCs at dose 10 mg
curcumin/kg body weight and (5) CNCs at dose 20 mg curcumin/kg body weight. Animals were treated three times/week with either BNCs or CNCs for 5 months. Results: The study revealed that CNCs 10 mg curcumin/kg body weight treated group had the highest survival rate (66.67%) while OV+NDMA group and OV+NDMA+BNCs were 40% survival rate. Gross appearance in CNCs 10 mg curcumin/kg body weight treated group was seen as the smallest tumor volume when compared with other induced groups. Histopathology of the liver using hematoxylin and eosin staining in this group showed an area of inflammation cell, cell proliferation, and precancerous
lesion in some hamsters. Immunohistochemical study of the liver showed higher expression of CK19 and HMGB1 in OV+NDMA and reduced in CNCs treated group. Conclusions: Our results suggest that CNCs at 10 mg curcumin/kg body weight has a potential effect to suppress tumor growth, reduce bile duct injury and also increase survival rate in animal experiments |
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| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
ชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Poster |
| Part of thesis |
true |
| Presentation awarding |
false |
| Attach file |
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| Citation |
0
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Journal Publication
ไทย