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Publication
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| Title of Article |
Cytotoxic and α-glucosidase inhibitory metabolites from twigs and leaves of Phyllanthus mirabilis, a species endemic to limestone mountains |
| Date of Acceptance |
20 November 2021 |
| Journal |
| Title of Journal |
Phytochemistry |
| Standard |
SCOPUS |
| Institute of Journal |
Elsevier |
| ISBN/ISSN |
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| Volume |
2022 |
| Issue |
194 |
| Month |
February |
| Year of Publication |
2021 |
| Page |
113028 |
| Abstract |
The first investigation of Phyllanthus mirabilis Müll.Arg. led to the isolation of six undescribed compounds
including two tyramine derivatives: phyllatyramines A and B; three butenolide analogues, phyllantenolide,
phyllantenocoside-O-gallate and epi-phyllantenocoside-O-gallate; and a flavanonol gallate, (− )-taxifolin-3-Ogallate; as well as two first isolated natural products, phyllatyramine C and phyllantenocoside; together with
twenty-three known compounds. Their structures were elucidated by spectroscopic means. ECD spectra of all
isolated butenolides were compared and assigned the configurations. Phyllatyramine A displayed weak cytotoxicity against the KB cell line, while phyllatyramines B and C showed weak cytotoxicity against KB and HeLa
cell lines. In addition, phyllatyramine B and (− )-taxifolin-3-O-gallate showed more potent α-glucosidase inhibitory activity than the standard acarbose 3.4 and 5.8 fold, respectively. |
| Keyword |
Phyllanthus mirabilis Phyllanthaceae Cytotoxicity α-Glucosidase inhibitory Tyramine derivative Butenolide glucoside Taxifolin-3-O-gallate |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
นานาชาติ |
| citation |
false |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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