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Publication
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| Research Title |
TA-AgNPs/Alginate hydrogel and its potential
application as a promising antibiofilm material against polymicrobial wound biofilms using a unique biofilm
flow model |
| Date of Distribution |
20 January 2023 |
| Conference |
| Title of the Conference |
The Pure and Applied Chemistry International Conference 2023 (PACCON2023) |
| Organiser |
The School of Science, Mae Fah Luang University and the Chemical Society of Thailand (CST) |
| Conference Place |
E4 Building, Mae Fah Luang University, Chiang Rai, Thailand |
| Province/State |
Chiang Rai, Thailand |
| Conference Date |
20 January 2023 |
| To |
21 January 2023 |
| Proceeding Paper |
| Volume |
- |
| Issue |
- |
| Page |
540 |
| Editors/edition/publisher |
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| Abstract |
Biofilm-growing bacteria have been shown to colonize and establish as a barrier and delay wound healing. The attached state of biofilms can promote a continuous inflammatory state in the wound, resulting in damage to the localized tissue. Hence, different wound dressing systems have been developed to prevent wound contamination and infection. Among all available systems, alginate-based nanocomposite hydrogels have received much attention due to their wound healing activity. We therefore aimed to develop an antimicrobial alginate hydrogel containing tannic acid stabilized silver nanoparticles (TA-AgNPs). Efficiency to inhibit polymicrobial wound biofilms was also demonstrated by using the biofilm flow device that allows simulation of chronic infection, exuding wound and wound environment to be performed. The TA-AgNPs/Alginate hydrogels were prepared by using a classic egg-box model and crosslinked by calcium alginate. The hydrogels containing TA-AgNPs appeared dark brown and turbid characters. We have demonstrated the biofilm flow device to test the topical antimicrobial hydrogel against the three-species biofilms. Neosporin® ointment was used as a positive control and exhibited a 3-4 log reduction in bacterial numbers as similar results as TA-AgNPs/Alginate hydrogel. These antimicrobial hydrogels showed the ability to significantly reduce the establishment of biofilm produced by the wound pathogens, Streptococcus pyogenes (MGA S6180), Staphylococcus aureus (EMRSA-15) and Pseudomonas aeruginosa (ATCC 9027). At 24-h intervals, these hydrogels also showed the ability to prevent bacterial tolerant post-treatment, especially for the case of P. aeruginosa chronic wound pathogen. This study has highlighted that the TA-AgNPs/Alginate hydrogel is a promising material for treating complex wound biofilms. |
| Author |
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| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
นานาชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Poster |
| Part of thesis |
true |
| Presentation awarding |
false |
| Attach file |
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| Citation |
0
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Journal Publication
ไทย