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Publication
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| Title of Article |
Effects of Plant Part Substitution in a Thai Traditional Recipe on α-Glucosidase Inhibition |
| Date of Acceptance |
17 May 2023 |
| Journal |
| Title of Journal |
Tropical Journal of Natural Product Research (TJNPR) |
| Standard |
SCOPUS |
| Institute of Journal |
Natural Product Research Group, University of Benin |
| ISBN/ISSN |
2616-0684 |
| Volume |
7 |
| Issue |
5 |
| Month |
June |
| Year of Publication |
2023 |
| Page |
2919-2925 |
| Abstract |
A Thai polyherbal antipyretic remedy, TPDM6315, consists of herbal constituents that possess
anti-diabetic properties. It contains 15 plants, of which the roots of 3 crude drugs, Solanum
indicum (R-Si), Solanum trilobatum (R-St), and Gymnopetalum integrifolium (R-Gi), are
insufficiently supplied in the herbal market, while their stems or aerial parts (S-Si, S-St, and S-Gi,
respectively), are available. This study aimed to determine the anti-diabetic properties of the recipe
extract and evaluate the possible substitution of those crude drugs. The chemical properties and
the in vitro -glucosidase inhibition were investigated in the single herbal ingredient and the
recipe extracts. The results indicated that TPDM6315 extracts inhibited -glucosidase as a mixedtype inhibitor. The high-performance liquid chromatography (HPLC) profiles between the root
and stem of those herbs were different but highly similar to the recipe extracts. The substituted
recipe (S-Et, containing S-Si, S-St, and S-Gi) exhibited higher potency on α-glucosidase inhibition
than the original recipe (R-Et, containing R-Si, R-St, and R-Gi) (P<0.01). This study revealed
substitution in TPDM6315 was possible for α-glucosidase inhibitory properties since it only
partially affected the overall chemical profile while raising the α-glucosidase inhibitory activity
of the recipe extracts.
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| Keyword |
anti-diabetes, alpha-glucosidase inhibition, Thai traditional medicine, herbal substitution |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
นานาชาติ |
| citation |
true |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
ไทย