| Research Title |
Association Of Microvascular Endothelial Dysfunction And Arterial Stiffness In Patients With Metabolic Syndrome |
| Date of Distribution |
3 May 2012 |
| Conference |
| Title of the Conference |
การประชุมวิชาการสรีรวิทยาสมาคมแห่งประเทศไทย (สสท.) ครั้งที่ 41 |
| Organiser |
สรีรวิทยาสมามคมแห่้งประเทสไทยและมหาวิทยาลัยมหิดล |
| Conference Place |
ณ ห้องประชุมอวย เกตุสิงห์ อาคารศรีสวรินทิรา ชั้น 3 คณะแพทยศาสตร์ศิริราชพยาบาล มหาวิทยาลัยมหิดล |
| Province/State |
กรุงเทพมหานคร |
| Conference Date |
2 May 2012 |
| To |
4 May 2012 |
| Proceeding Paper |
| Volume |
25 |
| Issue |
085 |
| Page |
49 |
| Editors/edition/publisher |
|
| Abstract |
Introduction. Individuals with metabolic syndrome (MetS) are thought to be prone to serious cardiovascular disease. Although impaired microvascular endothelial function and arterial stiffness are seriously symptoms associated with MetS, the data on the correlation between microvascular endothelial dysfunction and arterial stiffness in MetS patients is very limited. The objective is to investigate microvascular endothelial function by measuring forearm blood flow (FBF) and arterial stiffness by measuring pulse wave velocity (PWV) in patients with MetS, and to explore the relationship among these changes.
Medthods. Two hundred and thirty-six participants with mean age of 59.5 ± 10 years (range 38 to 85 years and 57% men) were enrolled in this study. Routine anthropometric and serologic data were collected. The two non-invasive techniques for measurement of FBF and PWV were used for assessment of endothelial function and arterial stiffness in the study patients.
Results. One hundred and forty five patients were classified as MetS according to the National Cholesterol Educational Program-Adult Treatment Panel III (NCEP-ATPIII). Brachial-ankle PWV (baPWV), aortic-ankle PWV (aaPWV) and aortic-femoral PWV (afPWV) were significantly increased in MetS patients (p< 0.001). The maximal change of FBF during reactive hyperemia in MetS was lower than non-MetS patients. There was a negative correlation between afPWV and maximum hyperemic FBF (r = -0.267, p < 0.001). This association remained significant (r = -0.214, p = 0.003) after adjusted for age and sex. Conclusion. In patients with MetS, a more impairment of response of FBF during reactive hyperemia showed a faster afPWV. Data of this study suggests an established measurement of central arterial stiffness with a non-invasive index of micro vascular endothelial dysfunction in MetS patients.
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| Author |
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| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
ชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Poster |
| Part of thesis |
true |
| Presentation awarding |
false |
| Attach file |
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| Citation |
0
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Publication
Journal Publication
ไทย