| Research Title |
Effect Of Long-Term Exposure To Low Levels Of Lead And Cadmium On Oxidative Stress And Vascular Function In Rats |
| Date of Distribution |
4 May 2012 |
| Conference |
| Title of the Conference |
การประชุมวิชาการสรีรวิทยาสมาคมแห่งประเทศไทย (สสท.) ครั้งที่ 41 “Obesity: size does matter” |
| Organiser |
สรีรวิทยาสมาคมแห่งประเทศไทย |
| Conference Place |
คณะแพทยศาสตร์ ศิริราชพยาบาล |
| Province/State |
บางกอกน้อย กรุงเทพมหานคร |
| Conference Date |
2 May 2012 |
| To |
4 May 2012 |
| Proceeding Paper |
| Volume |
25 |
| Issue |
1 |
| Page |
37 |
| Editors/edition/publisher |
|
| Abstract |
Introduction. Lead (Pb) and cadmium (Cd), which are highly toxic metals, have been contaminated in human stuff and environment as a consequence of increasing industrialization. Long-term exposure to these metals causes adverse health effects. Toxic metal-induced oxidative stress has been proposed to be the risk factor for developing hypertension and diabetes. Therefore, this study aimed to determine the effects of Pb and Cd either alone or in combination on blood pressure, vascular responsiveness, oxidative stress, and blood glucose level.
Methods. Low dose of lead acetate (100 mg/L) and/or cadmium chloride (10 mg/L) were administered as drinking water to male Sprague-Dawley rats for 12 weeks (n=6/group). Thereafter, oral glucose tolerance test (OGTT, 2 g glucose/BW) was performed in all animals. Arterial blood pressure and vascular reactivity to vasoactive agents were measured. Oxidative stress markers and antioxidant glutathione (GSH) were assessed.
Results. Increased arterial blood pressure and blunted vascular responses were found in rats exposed to Cd and/or Pb (p<0.05). Lipid peroxidation as indicated by the levels of malondialdehyde in plasma and tissues (kidneys and heart) were also elevated, and this was concurrent with a rise of superoxide production in the thoracic aortas (p<0.01). These deleterious effects are more pronounced in rats treated with Pb plus Cd than those treated with Cd or Pb alone. Impaired glucose tolerance was found in all Pb and/or Cd treated group. Moreover, increased fasting blood glucose level were also found in rats after exposed to Pb plus Cd for 12 weeks (p<0.01).
Conclusion Long-term exposure to Pb and Cd induced high blood pressure and vascular dysfunction. These alterations might be associated with chronic complications of glucose metabolism disorders. The overall findings suggest that toxic metals may play a role in development of diabetes and cardiovascular disease.
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| Author |
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| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
ชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Oral |
| Part of thesis |
true |
| Presentation awarding |
false |
| Attach file |
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| Citation |
0
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Publication
Journal Publication
ไทย