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Publication
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| Title of Article |
Diabetes mellitus: Possible risk and promoting factors of cholangiocarcinoma: Association of diabetes mellitus and cholangiocarcinoma. |
| Date of Acceptance |
5 April 2015 |
| Journal |
| Title of Journal |
Cancer Epidemiology |
| Standard |
ISI |
| Institute of Journal |
The International Journal of Cancer Epidemiology, Detection, and Prevention |
| ISBN/ISSN |
1877-7821 |
| Volume |
39 |
| Issue |
3 |
| Month |
June |
| Year of Publication |
2016 |
| Page |
274-278 |
| Abstract |
The highest incidence of Cholangiocarcinoma (CCA), a malignancy of bile duct epithelia, is in the
Northeast of Thailand. The liver fluke, Opisthorchis viverrini, is the known risk factor for CCA development
in this region. Approximately 1% of O. viverrini infected individuals develop CCA. There could be other
factors that influence the cholangiocarcinogenesis particularly in the O. viverrini infected individuals.
The global epidemiological studies of risk factors for CCA in non-O. viverrini related patients indicated
diabetes mellitus (DM) as a risk factor of CCA. The molecular studies in many cancers indicated that high
levels of glucose, insulin and an obese condition directly and indirectly enhanced growth of cancers. For
O. viverrini associated CCA, there is limited information related to DM and CCA development. High
mortality rates of CCA and DM, however, were reported in the same geographical areas of northeastern
Thailand. Whether DM is a factor that enhances CCA development in O. viverrini infected individuals or
promotes CCA progression are discussed in a perspective of epidemiological and molecular studies. |
| Keyword |
Diabetes mellitus, Hyperglycemia, Cholangiocarcinoma, Opisthorchis viverrini, Cancer risk |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
นานาชาติ |
| citation |
true |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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