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Journal Publication
Title of Article Ellagic Acid Prevents L-NAME-Induced Hypertension via Restoration of eNOS and p47phox Expression in Rats 
Date of Acceptance 23 June 2015 
Journal
     Title of Journal Nutrients 
     Standard SCOPUS 
     Institute of Journal MDPI 
     ISBN/ISSN doi:10.3390/nu7075222 
     Volume
     Issue
     Month july
     Year of Publication 2015 
     Page 5265-5280 
     Abstract The effect of ellagic acid on oxidative stress and hypertension induced by Nω-Nitro-L-arginine methyl ester hydrochloride (L-NAME) was investigated. Male Sprague-Dawley rats were administrated with L-NAME (40 mg/kg/day) for five weeks. L-NAME induced high systolic blood pressure (SBP) and increased heart rate (HR), hindlimb vascular resistance (HVR) and oxidative stress. Concurrent treatment with ellagic acid (7.5 or 15 mg/kg) prevented these alterations. Co-treatment with ellagic acid was associated with up-regulation of endothelial nitric oxide synthase (eNOS) protein production and alleviation of oxidative stress as indicated by decreased superoxide production in the vascular tissue, reduced plasma malondialdehyde levels, reduced NADPH oxidase subunit p47phox expression and increased plasma nitrate/nitrite levels. Our results indicate that ellagic acid attenuates hypertension by reducing NADPH oxidase subunit p47phox expression, which prevents oxidative stress and restores NO bioavailability. 
     Keyword ellagic acid; high blood pressure; nitric oxide deficiency; NADPH oxidase; antioxidant 
Author
557070007-3 Mr. THEWARID BERKBAN [Main Author]
Medicine Doctoral Degree
577070001-7 Mr. PATTANAPONG BOONPROM
Medicine Doctoral Degree
557070037-4 Mr. SARAWOOT BUNBUPHA
Medicine Doctoral Degree

Reviewing Status มีผู้ประเมินอิสระ 
Status ตีพิมพ์แล้ว 
Level of Publication นานาชาติ 
citation true 
Part of thesis true 
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