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Publication
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| Research Title |
Antidepressant‐like effect of Citrus grandis fruit juice
on unpredictable chronic mild stress in mice model |
| Date of Distribution |
21 January 2016 |
| Conference |
| Title of the Conference |
The 6th International Conference on Natural Product for Health and Beauty (NATPRO6) |
| Organiser |
คณะเภสัชศาสตร์, คณะเทคโนโลยี, ศูนย์วิจัยและพัฒนาผลิตภัณฑ์สุขภาพจากสมุนไพร, ศูนย์วิจัยการหมักเพิ่มเพิ่มมูลค่าผลิตภัณฑ์ทางการเกษตร มหาวิทยาลัยขอนแก่น |
| Conference Place |
โรงแรมพูลแมน ราชา ออคิด |
| Province/State |
ขอนแก่น |
| Conference Date |
21 January 2016 |
| To |
23 January 2016 |
| Proceeding Paper |
| Volume |
ุ6 |
| Issue |
1 |
| Page |
161 |
| Editors/edition/publisher |
Professor Bungorn Sripanidkulchai |
| Abstract |
Citrus grandis (Burm.) Merrill also known as Pomelo is the largest of all Citrus, the native fruit of great economic in Thailand. The evident shown that the antioxidant potential of pomelo. In this
study aimed to investigate antidepressant‐like behavior in mice to unpredictable chronic mild stress (UCMS) to clarify the antidepressant‐like activity of pomelo cultivar Tubtim Siam (TS). UCMS has been used as a model of depression and also has a combination of a strong predictive, face and
construct validity. UCMS‐induced depression can be reversed by antidepressant treatment. In
experiment the UCMS mice were administered TS daily (250, 500 mg/kg, p.o.) or imipramine, a
reference antidepressant (IMP 20 mg/kg, i.p.), 2 week after stating the UCMS procedure. We
employed the sucrose preference test to analyze anhedonia‐like behavior, tail suspension test (TST)
and forced swimming test (FST) to analyze depression‐like behavior. The UCMS procedure induced anhedonia and depressive‐like behavior, and TS (500 mg/kg, p.o.) treatment, as well as IMP
treatment, alleviated these symptoms. TS significantly decreased the immobility time in both TST and FST without the direct effect on locomotor activity. These results suggest that TS exerted
antidepressant‐like activity and may have a benefit in the future. The plausible mechanism should be
further investigated. |
| Author |
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| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
นานาชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Poster |
| Part of thesis |
true |
| Presentation awarding |
false |
| Attach file |
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| Citation |
0
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Journal Publication
ไทย