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Publication
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| Research Title |
Garcinia mangostana pericarp extract alleviates hypertension and normalizes morphological changes of resistance artery via oxidative stress reduction in NO-deficient hypertensive rats |
| Date of Distribution |
27 October 2016 |
| Conference |
| Title of the Conference |
The 7th Scientific Meeting of Asian Society for Vascular Biology |
| Organiser |
Asian Society for Vascular Biology |
| Conference Place |
The Buddhist Tzu Chi General Hospital |
| Province/State |
Hualien, Taiwan |
| Conference Date |
27 October 2016 |
| To |
29 October 2016 |
| Proceeding Paper |
| Volume |
2016 |
| Issue |
1 |
| Page |
1 |
| Editors/edition/publisher |
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| Abstract |
Oxidative stress plays a role in enhancing high blood pressure and contributes to the vascular changes in Nω-nitro-L-arginine methyl ester (L-NAME)-induced hypertension. Consumption of polyphenol-rich foods can protect cells or molecules from oxidative vascular injury. Garcinia mangostana Linn. has an antioxidant property. The present study was designed to investigate the preventive effect of Garcinia mangostana pericarp extract (GME) on hemodynamic status, oxidative stress and morphology of resistance artery in nitric oxide-deficient hypertensive rats. Male Sprague-Dawley rats were given L-NAME 40 mg/kg/day in drinking water to induce hypertension, and simultaneously treated with GME at dose 300 mg/kg/day. Rats received L-NAME for 5 weeks had high systolic blood pressure, low hindlimb blood flow and high hindlimb vascular resistance. Vascular superoxide production and plasma malondialdehyde (MDA) were significantly increased in L-NAME hypertensive rats (p < 0.05). In 2nd order branch of mesenteric artery, vascular wall thickness, cross sectional area were increased while lumen diameter was reduced in L-NAME hypertensive rats (p < 0.05). Supplementation with GME markedly reduced blood pressure, improved hemodynamic alterations, alleviated oxidative stress, and normalized the morphological changes of the 2nd order branch of mesenteric artery (p < 0.05). These data suggest that GME ameliorates high blood pressure, hemodynamic alterations via normalized the geometry of the resistance artery. The mechanism could be attributed to its antioxidant activity. Thus, these findings demonstrated that GME could be a supplement agent for the hypertensive management. |
| Author |
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| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
นานาชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Poster |
| Part of thesis |
true |
| Presentation awarding |
false |
| Attach file |
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| Citation |
0
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Journal Publication
ไทย