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Publication
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| Research Title |
Investigation of wound healing properties of Crocodylus siamensis serum on human keratinocyte cells (HaCaT) |
| Date of Distribution |
11 July 2017 |
| Conference |
| Title of the Conference |
The 5th Asia Pacific Protein Association (APPA) Conference and the 12th International Symposium for the Protein Society of Thailand (PST) |
| Organiser |
Protein Society of Thailand (PST) |
| Conference Place |
The Tide Resort, Bangsaen |
| Province/State |
Chonburi |
| Conference Date |
11 July 2017 |
| To |
14 July 2017 |
| Proceeding Paper |
| Volume |
2017 |
| Issue |
1 |
| Page |
145 |
| Editors/edition/publisher |
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| Abstract |
Blood serum represents an important component of whole blood, and can be conveniently derived by centrifugation thereof. In a previous study, Crocodylus siamensis serum has been reported to display a broad range of biological properties, such as antimicrobial and anti-inflammatory activity, which play a crucial role for supporting the wound recovery process involving the formation of new tissue around the injured skin. However, only limited information regarding the wound healing properties of C. siamensis serum have been reported to date. Therefore, the aim of this study was to investigate wound healing activity of C. siamensis serum using an in vitro model. Human keratinocyte cells (HaCaT) were used to study the effects of C. siamensis serum treatment on cell migration and cell proliferation by a scratch wound healing assay. After 48 h of treatment, C. siamensis serum at a concentration of 50 µg/ml and 100 µg/ml showed the ability to activate migration and proliferation of HaCaT cells. The percentages of wound closure after treatment with 50 µg/ml and 100 µg/ml of serum for 48 h were 74.47% and 92.26%, respectively, indicating a dose-dependent narrowing of the incised wound occurred. The collected results suggest that C. siamensis serum is capable of promoting the wound healing ability of HaCaT cells, which might be utilized in the development of novel therapeutic material for wound treatment in the future |
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| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
นานาชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Poster |
| Part of thesis |
true |
| Presentation awarding |
false |
| Attach file |
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| Citation |
0
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Journal Publication
ไทย