| Abstract |
The novel therapeutic strategy against autism is essential due to the limited therapeutic
efficacy. Based on the benefit of laser acupuncture at HT7 acupoint on the neurological
disorders related with oxidative stress and inflammation, its benefit on oxidative stress,
neuroinflammation, and GABAergic/glutamatergic imbalance in cerebellum of autism
have been considered. To elucidate this issue, male rat pups were induced autistic-like
conditions by valproic acid (VPA) and treated with laser acupuncture at HT7 acupoint
once daily between postnatal Day 14 and Day 40. At the end of study, the changes of
oxidative stress markers, the expressions of cytokines interleukin 6 (IL-6) and glutamic
acid decarboxylase (GAD) proteins (65 kDa and 67 kDa) together with gammaaminobutyric
acid transaminase (GABA-T) activity and density of Purkinje cell in the cerebellum
were assessed. The results showed that laser acupuncture HT7 decreased oxidative
stress, IL-6 expression, and GABA-T activity but increased the expressions of GAD 65
kDa together with the density of Purkinje cells in the cerebellum. Therefore, laser
acupuncture at HT7 is the potential strategy to improve the cerebellar disorders in
VPA-rat model of autism. The mechanism may occur partly via the decrease of oxidative
stress status, inflammation, and the improved GABAergic function. |
Publication
Journal Publication
ไทย