| Abstract |
The increasing use of herbs, which are often administered in combination with conventional drugs, may result in
the potential for herb-drug interaction. Tiliacora triandra (Colebr.) Diels has long been used in traditional medicine, as well
as in Thai cuisine, but there remains insufficient understanding of the herb-drug interaction. This study aimed to investigate
the influence of aqueous extracts of T. triandra (TTA) on the efflux of digoxin, studied in the everted intestines of rats. Male
Sprague-Dawley rats were orally administered with TTA (0.5, 1.0, and 2.0 g/kg BW) once daily, for seven days; after which,
the digoxin efflux was examined in the everted intestines. Our results found that at low dosage of TTA modulated the efflux
of digoxin. Administration of TTA (0.5 and 1.0 g/kg BW) significantly increased the efflux rate of digoxin to 1.16; 1.51 times
higher than the control. Moreover, when the concentration of TTA was increased (2.0 g/kg BW), a significant decrease in
the digoxin efflux was observed. The efflux rate was dramatically reduced to 0.34, 0.29, and 0.22 times lower than control
and TTA (0.5 and 1.0 g/kg BW) treated groups, respectively. This study represents the first insight into the interaction of T.
triandra with the conventional drug digoxin. The interaction may involve a biphasic effect, involving the induction or inhibition
of the drug transporter P-gp. However, the mechanism of interaction and the interference with the pharmacokinetics of
digoxin require further study. |
Publication
Journal Publication
ไทย