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Publication
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| Title of Article |
Neuroprotective and Cognitive-Enhancing Effects of Microencapsulation of Mulberry Fruit Extract in Animal Model of Menopausal Women with Metabolic Syndrome |
| Date of Acceptance |
19 September 2017 |
| Journal |
| Title of Journal |
Oxidative Medicine and Cellular Longevity |
| Standard |
ISI |
| Institute of Journal |
Hindawi Publishing Corporation |
| ISBN/ISSN |
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| Volume |
2017 |
| Issue |
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| Month |
October |
| Year of Publication |
2017 |
| Page |
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| Abstract |
Currently, the neuroprotectant and memory enhancing agent for menopausal women with metabolic syndrome is required. Based on the advantages of polyphenolics on numerous changes observed in menopause with metabolic syndrome and the encapsulation method, we hypothesized that microencapsulated mulberry fruit extract (MME) could protect brain damage and improve memory impairment in animal model of menopause with metabolic syndrome. To test this hypothesis, MME at doses of 10, 50 and 250 mg/kg were given to female Wistar rats which were induced experimental menopause with metabolic syndrome by bilateral ovariectomy (OVX) and fed with high carbohydrate high fat (HCHF) diet for 8 weeks. Spatial memory together with neuron density, oxidative stress status, acetylcholinesterase and phosphorylation of Erk in the hippocampus were assessed at the end of study. It was found that MME decreased memory impairment, oxidative stress status and AChE activity but increased neuron density and Erk phosphorylation in hippocampus. Therefore, the neuroprotective and memory enhancing effects of MME might partly involve the enhanced cholinergic function and Erk phosphorylation but decreased oxidative stress status in hippocampus. Therefore, MME is the potential novel neuroprotectant and memory enhancing agent for menopause with metabolic syndrome. However, further research especially clinical trial is still necessary. |
| Keyword |
mulberry fruit, encapsulation, metabolic syndrome, menopause, neuroprotective, memory |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
นานาชาติ |
| citation |
false |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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