| Research Title |
EFFECT OF CANDIDONE, A COMPOUND FROM DERRIS INDICA, ON APOPTOSIS INDUCTION AND CELL MIGRATION SUPPRESSION IN CHOLANGIOCARCINOMA CELL LINE KKU-M156
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| Date of Distribution |
26 April 2018 |
| Conference |
| Title of the Conference |
งานประชุมวิชาการประจำปีสมาคมเภสัชวิทยาแห่งประเทศไทย ครั้งที่ 40 |
| Organiser |
สมาคมเภสัชวิทยาแห่งประเทศไทย |
| Conference Place |
คณะวิทยาศาสตร์ มหาวิทยาลัยมหิดล พญาไท |
| Province/State |
กรุงเทพฯ |
| Conference Date |
26 April 2018 |
| To |
28 April 2018 |
| Proceeding Paper |
| Volume |
61 |
| Issue |
40 |
| Page |
130-137 |
| Editors/edition/publisher |
|
| Abstract |
Cholangiocarcinoma (CCA) is a fatal malignancy that arising from biliary epithelium. To date, there is no curative treatment options except surgery. However, most of CCA patients are in inoperable stage. Thus, effective anticancer agents are urgently needed to improve treatment outcome for CCA patients. Candidone (CD) is a flavanone compound from Derris indica, exhibits anticancer activity against various cancer cells. Here, we investigated the antitumor effects of CD in CCA cells. CD showed potent cytotoxicity on KKU-M156 cells with the IC50 of 4.24 µg/mL at 24 h. It significantly inhibited cell migration and induced apoptosis. In addition, CD exerted antitumor effect through upregulation of anti-proliferative and pro-apoptotic genes, p21 and Bax, respectively. Our findings suggest that CD could be a potential anticancer agent for CCA treatment. |
| Author |
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| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
ชาติ |
| Type of Proceeding |
Full paper |
| Type of Presentation |
Poster |
| Part of thesis |
true |
| Presentation awarding |
false |
| Attach file |
|
| Citation |
0
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Publication
Journal Publication
ไทย