| Title of Article |
Effect of Syzygium gratum extract on Blood Pressure and Endothelium-Dependent Vasorelaxation in Nitric Oxide-Deficient Rats. |
| Date of Acceptance |
16 February 2018 |
| Journal |
| Title of Journal |
ศรีนครินทร์เวชสาร (Srinagarind Medical Journal) |
| Standard |
TCI |
| Institute of Journal |
ฝ่ายวิชาการ คณะแพทยศาสตร์ มหาวิทยาลัยขอนแก่น |
| ISBN/ISSN |
08573123 |
| Volume |
33 |
| Issue |
1 |
| Month |
กุมภาพันธ์ |
| Year of Publication |
2018 |
| Page |
38 |
| Abstract |
Background and Objectives: Syzygium gratum (Pakmek) show antioxidant and vascular protective effects in experimental animal models. This study was to investigate whether Syzygium gratum extract could alleviate high blood pressure and vascular dysfunction in Nω-Nitro-l-arginine methyl ester (L-NAME)-induced hypertension in rats.
Methods: Male Sprague-Dawley rats weighing 180-200 g were treated with L-NAME (40 mg/kg/day) in drinking water for five weeks and orally treated with Syzygium gratum (300 mg/kg BW per day) for the last two week. Mean arterial blood pressure (MAP) and heart rate (HR) was measured at the end of experiment. Vascular responses to acetylcholine (ACh, 1 nM-0.01 µM) and sodium nitroprusside (SNP, 1 nM-0.01 µM) were performed in isolated mesenteric vascular beds.
Results: Rats treated with L-NAME had high blood pressure (MAP; 153.85 ± 7.7 mmHg vs. 91.4 ± 2.72 mmHg) and heart rate (415.0 ± 1.0 beats/min vs. 355.8 ± 15.3 beats/min) comparing to control rats (p<0.05). Vasorelaxation to ACh was blunted in L-NAME treated rats (p<0.05) while the response to SNP was not different among groups. Furthermore, Syzygium gratum extract significantly reduced blood pressure in L-NAME hypertension (121.75 ± 8.1 mmHg) and HR (380.3 ± 16.5 beats/min) comparing to those of untreated rats. L-NAME rats received Syzygium gratum extract had an improvement of vascular response to ACh (p<0.05).
Conclusion: These findings suggested that Syzygium gratum extract reduced blood pressure and HR in hypertension induced by L-NAME. This antihypertensive effect could involve the improvement of endothelium-dependent vasorelaxation in L-NAME hypertension.
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| Keyword |
Syzygium gratum, L-NAME-induced hypertensive rats,Vascular dysfunction |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
ชาติ |
| citation |
true |
| Part of thesis |
true |
| Attach file |
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| Citation |
1
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Publication
Journal Publication
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