| Research Title |
Antihypertensive Effects of Sung Yod Rice Bran Hydrolysates in LNAME-induced Hypertensive Rats |
| Date of Distribution |
7 December 2017 |
| Conference |
| Title of the Conference |
45th Physiological society of Thailand annual meeting |
| Organiser |
ภาควิชาสรีรวิทยา คณะแพทยศาสตร์ มหาวิทยาลัยขอนแก่น และ สรีรวิทยาสมาคมแห่งประเทศไทย |
| Conference Place |
โรงแรมอะวานี ขอนแก่น |
| Province/State |
ขอนแก่น |
| Conference Date |
6 December 2017 |
| To |
8 December 2017 |
| Proceeding Paper |
| Volume |
2017 |
| Issue |
1 |
| Page |
26 |
| Editors/edition/publisher |
|
| Abstract |
Hypertension is one of the major risk factors for cardiovascular disease (CVD). Consumption of dietary antioxidants appears to reduce blood pressure and may help lower risk for CVD. Sung Yod rice is red-violet pigmented rice and grown mainly in southern part of Thailand. Rice bran hydrolysates contain highly nutritional proteins and antioxidant compounds which show benefits against hypertension. However, the antihypertensive effect of rice bran hydrolysates extracted from Sung Yod rice bran has not been investigated. Nitric oxide (NO) is a widespread biological mediator involved in many physiological and pathological processes, Inhibition of NO synthase by N𝝎-nitro-L-arginine methyl ester (L-NAME) results in the development of hypertension accompanied with increased oxidative stress. The present study aimed to evaluate the antihypertensive effect of Sung Yod rice bran hydrolysates in a rat model of hypertension. Hypertension was induced in male Sprague-Dawley rats by administration of L-NAME (50 mg/kg/day) in their drinking water for 3 weeks. Sung Yod rice bran hydrolysates (SY) were orally administered daily at doses of 250 and 500 mg/kg. Rats received tap water as drinking water and orally administered with deionized water were served as normotensive controls. Results showed that L-NAME-treated rats exhibited an increase in blood pressure and peripheral vascular resistance compared with control rats, and SY treatment significantly restored these parameters (P<0.05). Increased markers of oxidative stress (superoxide anion, MDA, protein carbonyl) and decreased NO metabolites level were found in L-NAME hypertensive rats, and SY significantly mitigated these deleterious effects (P<0.05). The present study reported for the first time that Sung Yod rice bran hydrolysates may be useful for prevention and treatment of hypertension. Its antihypertensive effect might be due to the ability to increase the production of NO and antioxidant properties. |
| Author |
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| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
ชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Oral |
| Part of thesis |
true |
| Presentation awarding |
false |
| Attach file |
|
| Citation |
0
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|
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Publication
Journal Publication
ไทย