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Publication
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| Research Title |
Whole Grain Essential Oil Mitigates Hypertension, Endothelial Dysfunction and Oxidative Stress in Rats with Nitric Oxide Deficient Hypertension |
| Date of Distribution |
22 January 2018 |
| Conference |
| Title of the Conference |
Innovation of Functional Foods in Asia (IFFA) Functional Foods: Trends in Research and Markets |
| Organiser |
คณะวิยาศาสตร์การแพทย์ มหาวิทยาลัยพะเยา |
| Conference Place |
ICT Building, University of Phayao, Phayao Province, Thailand |
| Province/State |
พะเยา |
| Conference Date |
22 January 2018 |
| To |
24 January 2018 |
| Proceeding Paper |
| Volume |
2018 |
| Issue |
1 |
| Page |
130 |
| Editors/edition/publisher |
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| Abstract |
Introduction: Hypertension is a major risk factor for cardiovascular disease (CVD). Endothelial dysfunction associated with increased oxidative stress is manifested in hypertension. Consumption of antioxidants appears to prevent hypertension and reduces risk for CVD. Rice bran oil is one of the most nutritious oils due to its favorable fatty acid composition and rich in many antioxidant compounds. Rice bran oil is used for cholesterol lowering supplements. However, its effect on lower blood pressure remains unclear. Therefore, the present study aimed to evaluate the antihypertensive effect of whole grain essential oil (WEO) in a rat model of nitric oxide (NO) deficient hypertension.
Materials and Methods: Hypertension was induced in male Sprague-Dawley rats by administering N𝝎-nitro-L-arginine methyl ester (L-NAME), a nitric oxide synthase (NOS) inhibitor, at dose of 50 mg/kg via drinking water for 3 weeks. WEO was intragastrically administered daily at doses of 1 and 2 ml/kg for 3 weeks. Rats received tap water and intragastrically administered with deionized water (DI) were served as normotensive controls. Hemodynamis, vascular responsiveness, oxidative stress status and plasma NO metabolites (NOx) levels were measured.
Results: A marked increase in blood pressure and peripheral vascular resistance was found in L-NAME-treated rats. WEO supplementation significantly reduced blood pressure, increased hindlimb blood flow and reduced hindlimb vascular resistance of L-NAME-treated rats as compared to controls (P<0.05). The improvement of vasodilatory responses to acetylcholine, an endothelium-dependent vasodilator, was found in L-NAME rats treated with WEO (P<0.05). Moreover, WEO significantly decreased vascular superoxide production and reduced plasma concentrations of malondialdehyde, protein carbonyl and increased NOx in L-NAME-treated rats (P<0.05).
Conclusions: Results of this study suggest that WEO may be used as dietary supplementation to reduce blood pressure, preserve vascular function and decrease oxidative stress.
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| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
นานาชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Poster |
| Part of thesis |
true |
| Presentation awarding |
false |
| Attach file |
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| Citation |
0
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Journal Publication
ไทย