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Publication
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| Research Title |
Cytotoxic and antimalarial constituents from the roots of Atalantia monophylla
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| Date of Distribution |
7 February 2018 |
| Conference |
| Title of the Conference |
The Pure and Applied Chemistry International Conference 2018 (PACCON 2018) |
| Organiser |
The Pure and Applied Chemistry International Conference 2018 (PACCON 2018) |
| Conference Place |
Prince of Songkla University |
| Province/State |
Songkhla, Thailand |
| Conference Date |
7 February 2018 |
| To |
9 February 2018 |
| Proceeding Paper |
| Volume |
1 |
| Issue |
1 |
| Page |
NP26 |
| Editors/edition/publisher |
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| Abstract |
Three known acridone alkaloids, atalaphylline (1), N-methylatalaphylline (2), and N-methylatalaphyllinine (3), as well as three known coumarins, 2,2-dimethylchromenocoumarin (4), auraptene (5) and 7-O-geranylscopoletin (6) were isolated from the n-hexane extract of the roots of Atalantia monophylla. Their structures were elucidated on the basis of spectroscopic analyses (1D and 2D NMR). Compounds 1, 2 and 3 possess appreciable anti-malarial activity against Plasmodium falciparum with IC50 values of 2.9, 2.6 and 1.3 μg/mL, respectively. Additionally, they displayed cytotoxicity against KB, NCI-H187 and MCF-7 cell lines with IC50 values ranging from 5.8 to 21.1 μg/mL. |
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| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
นานาชาติ |
| Type of Proceeding |
Full paper |
| Type of Presentation |
Poster |
| Part of thesis |
true |
| Presentation awarding |
false |
| Attach file |
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| Citation |
0
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Journal Publication
ไทย