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Publication
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| Research Title |
ANTIPROLIFERATIVE AND APOPTOSIS INDUCTION ACTIVITIES OF Croton stellatopilosus OHBA. LEAF POWDER WATER EXTRACT AGAINST COLON CANCER CELL LINES |
| Date of Distribution |
17 October 2017 |
| Conference |
| Title of the Conference |
การประชุมวิชาการวิทยาศาสตร์และเทคโนโลยีแห่งประเทศไทย ครั้งที่43 |
| Organiser |
สมาคมวิทยาศาสตร์แห่งประเทศไทยในพระบรมราชูปถัมภ์ |
| Conference Place |
อาคารเฉลิมราชกุมารี 60 พรรษา จุฬาลงกรณ์มหาวิทยาลัย |
| Province/State |
กรุงเทพมหานคร |
| Conference Date |
17 October 2017 |
| To |
19 October 2017 |
| Proceeding Paper |
| Volume |
43 |
| Issue |
43 |
| Page |
145-150 |
| Editors/edition/publisher |
Lakkhana Charoenprom, Gulsiri Senawong, Thanaset Senawong* |
| Abstract |
Plaunoi (Croton stellatopilosus Ohba.), a Thai medicine plant, has been used for the treatment of various diseases, especially peptic ulcer and related gastrointestinal diseases. The aim of this study was to investigate anti-proliferative and apoptosis induction activities of Plaunoi leaf powder water extract in colon cancer cell lines (HT29 and HCT116 cells) and a non-cancer cell line (Vero cells) by MTT and Vybrant Apoptosis assays, respectively. The water extract inhibited proliferation of HT29 and HCT116 cells at exposure times of 24, 48, and 72 h with IC50 values of 403.83 ± 3.40, 371.26 ± 2.17, 326.03 ± 3.04 µg/ml and 461.34 ± 4.17, 379.66 ± 20.99, 274.97 ± 21.57 µg/ml, respectively. In contrast, the water extract inhibited the growth of the non cancer Vero cells with IC50 values of 841.14 ± 19.54, 765.93 ± 37.34, 733.24 ± 5.32 µg/ml at exposure times of 24, 48, and 72 h, respectively. The water extract at concentrations of 100, 200 and 400 µg/ml induced apoptosis of colon cancer cell lines (HT29 and HCT116) in a concentration dependent manner but induced less apoptotic cell death in Vero cells. |
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| Peer Review Status |
ไม่มีผู้ประเมินอิสระ |
| Level of Conference |
ชาติ |
| Type of Proceeding |
Full paper |
| Type of Presentation |
Poster |
| Part of thesis |
true |
| Presentation awarding |
false |
| Attach file |
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| Citation |
0
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Journal Publication
ไทย