|
|
Publication
|
| Title of Article |
Acetylcholinesterase inhibition and cytotoxicity of flavonoids and chalcones from Derris indica |
| Date of Acceptance |
11 September 2016 |
| Journal |
| Title of Journal |
ScienceAsia |
| Standard |
ISI |
| Institute of Journal |
THE NATIONAL RESEARCH COUNCIL OF THAILAND (NRCT) |
| ISBN/ISSN |
|
| Volume |
42 |
| Issue |
4 |
| Month |
|
| Year of Publication |
2016 |
| Page |
247-251 |
| Abstract |
Derris indica, a Thai medicinal plant, contains biologically active substances such as flavone, flavanone, chalcone, and rotenoid compounds. Many compounds from this plant show antitumour, antihyperglycaemic, and anti-inflammatory activities. In this study, eleven compounds including six flavonoid and five chalcone compounds were isolated from the seed of D. indica. Their structures were established on the basis of NMR spectroscopic data. Desmethoxykanugin showed 100% inhibition to acetylcholinesterase, being about two fold stronger than the standard, tacrine, but cytotoxic against normal cells. Fortunately, pongaflavone and (2R,3R)-3-hydroxy-5-methoxy-
200,200-dimethylpyrano[7,8:500,600]-flavanone displayed around 50% inhibition to AChE as compared to the standard and they were inactive against normal cells. Thus these compounds could be developed to treat Alzheimer’s disease.
In addition, candidone, pongamol, obovatachalcone, derrischalcone, and tunicatachalcone showed cytotoxic activity
against KB cell line with IC50 values ranging from 8–18 µg/ml |
| Keyword |
Alzheimer’s disease, KB cells, desmethoxykanugin, pongaflavone, pongamol |
| Author |
|
| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
นานาชาติ |
| citation |
false |
| Part of thesis |
true |
| Attach file |
|
| Citation |
0
|
|
|
|
|
|
|
|
|
Journal Publication
ไทย