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Publication
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| Title of Article |
Benzoyltyramine Alkaloids Atalantums A–G from the Peels of Atalantia monophylla and Their Cytotoxicity against Cholangiocarcinoma Cell Lines |
| Date of Acceptance |
31 January 2017 |
| Journal |
| Title of Journal |
Journal of natural products |
| Standard |
ISI |
| Institute of Journal |
American Chemical Society and American Society of Pharmacognosy |
| ISBN/ISSN |
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| Volume |
80 |
| Issue |
2 |
| Month |
February |
| Year of Publication |
2017 |
| Page |
403-408 |
| Abstract |
Seven new benzoyltyramines, atalantums A–G (1–7), and five known compounds were isolated from the peels of Atalantia monophylla. All compounds were examined for cytotoxicity against the cholangiocarcinoma cell lines KKU-M214, KKU-M213, and KKU-M156. Compound 5 exhibited the strongest cytotoxicity against KKU-M156 cells, with an IC50 value of 1.97 ± 0.73 μM, an approximately 4.7-fold higher activity than that of the ellipticine standard. Compound 1 displayed strong cytotoxicity against KKU-M214 cells, with an IC50 value of 3.06 ± 0.51 μM, nearly equal to that of the 5-fluorouracil standard. In the case of the KKU-M213 cell line, compounds 2, 4, and 11 exhibited stronger cytotoxicity than the ellipticine standard, with IC50 values of 2.36 ± 0.20, 5.63 ± 0.22, and 2.71 ± 0.23 μM, respectively. Compounds 1, 5, and 7 displayed cytotoxicity against KKU-M214 cells, with IC50 values of 3.06 ± 0.51, 8.44 ± 0.47, and 7.37 ± 1.29 μM, respectively. |
| Keyword |
Atalantum, Atalantia monophylla, Cholangiocarcinoma |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
นานาชาติ |
| citation |
true |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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