| Research Title |
Anti-hypertensive and anti-oxidative effects of whole grain essential oil in L-NAME-induced hypertensive rats |
| Date of Distribution |
22 December 2016 |
| Conference |
| Title of the Conference |
44th Physiological society of Thailand conference 2016 |
| Organiser |
ภาควิชาสรีรวิทยา คณะแพทยศาสตร์ มหาวิทยาลัยgเชียงใหม่ และ สรีรวิทยาสมาคมแห่งประเทศไทย |
| Conference Place |
โรงแรมดิเอ็มเพรส |
| Province/State |
จังหวัดเชียงใหม่ |
| Conference Date |
22 December 2016 |
| To |
24 December 2016 |
| Proceeding Paper |
| Volume |
2016 |
| Issue |
1 |
| Page |
63 |
| Editors/edition/publisher |
|
| Abstract |
Hypertension is a major risk factor for cardiovascular disease (CVD). Dietary antioxidants appear to reduce blood pressure and may help lower risk for CVD. Whole grain essential oil (WEO) has received considerable attention because it possesses strong antioxidant and various pharmacological activities. N𝝎-nitro-L-arginine methyl ester (L-NAME) is a nitric oxide synthase (NOS) inhibitor that induces hypertension by reducing nitric oxide (NO) bioavailability. This study aimed to investigate the anti-hypertensive and anti-oxidative effects of WEO in L-NAME-induced hypertensive rats. Male Sprague-Dawley rats were induced to be hypertensive by administration of L-NAME (50 mg/kg/day) in their drinking water for 3 weeks. WEO (2 ml/kg/day) or lisinopril (Lis), an angiotensin-converting enzyme (ACE) inhibitor (1 mg/kg/day) or WEO + Lis was intragastrically administered during 1 to 3 week of L-NAME administration. Rats received tap water as drinking water and intragastrically administered with deionized water were served as normotensive controls. Results showed that rats receiving L-NAME for 3 weeks had a significant change in hemodynamic status, including increased arterial blood pressure, decreased hindlimb blood flow and increased hindlimb vascular resistance when compared to controls (P<0.05). WEO, Lis or WEO + Lis significantly improved the hemodynamic status of L-NAME hypertensive rats (P<0.05). The anti-hypertensive effect of WEO and Lis was associated with a reduction in plasma ACE level, a decrease in vascular superoxide production, plasma malondialdehyde and plasma protein carbonyl, and an increase in blood glutathione and plasma NO metabolites. Interestingly, the combination of WEO and Lis had a greater effect than WEO or Lis monotherapy. These results suggest that WEO can help reduce the risk of developing hypertension. A plausible mechanism of WEO might be due to the anti-ACE and anti-oxidant activities. |
| Author |
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| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
ชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Poster |
| Part of thesis |
true |
| Presentation awarding |
false |
| Attach file |
|
| Citation |
0
|
|
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Publication
Journal Publication
ไทย