| Abstract |
Nontuberculous mycobacteria (NTM) is a group of mycobacteria that are not a cause of tuberculosis (TB) but can cause life threatening diseases with symptoms similar to TB. Mycobacterium abscessus is a rapid growing mycobacterium that causes a wide spectrum of disease in humans and is associated with drug resistance. The association between the drug susceptibility pattern and the colonial morphotypes of M. abscessus has not been fully investigated. In this study, we investigate the drug susceptibility results and the colonial morphotypes of M. abscessus isolated from patients at Srinagarind hospital in Khon Kaen, Thailand from 2012 to 2016. The morphologies M. abscessus colonies were divided into three types: rough, smooth, and mixed, the proportions of which were 48%, 20%, and 32%, respectively. We found that 46% of rough, 14% of smooth, and 23% of mixed colonies were susceptible to amikacin. Approximately half all types were susceptible to clarithromycin. These results show that the rough morphotype was dominant in clinical specimens and that there was no significant difference in susceptibility among the various morphologies (p < 0.05). Nearly all specimens of all colony types of were resistant to drugs used for treatment including cefoxitin, doxycycline, imipenem, moxifloxacin, Linezolid, ciprofloxacin, tobramycin, and trimetroprim/sulfamethoxazole. In summary, we did not find any association between colony morphology and drug resistance in M. abscessus. This emphasizes the magnitude of the problem of drug-resistant M. abscessus. |
Publication
Journal Publication
ไทย